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Antiretroviral

B/F/TAF for HIV (BEST-HBV Trial)

Phase 4
Waitlist Available
Led By Joel V Chua, MD
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 48
Awards & highlights

BEST-HBV Trial Summary

This trial will evaluate the efficacy and safety of a new drug combination for people with HIV and hepatitis B. The study will last 48 weeks.

Eligible Conditions
  • HIV
  • Hepatitis B

BEST-HBV Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 48
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 48 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
HBV DNA at Week 24
HIV-1 RNA at Week 24
Secondary outcome measures
ALT Normalization at Week 24
ALT Normalization at Week 48
CD4 Cell Count Change at Week 24
+5 more

Side effects data

From 2023 Phase 4 trial • 28 Patients • NCT03797014
18%
Upper respiratory tract infection
7%
Abdominal pain
7%
Abscess, extremity
7%
Back pain
7%
Headache
7%
Hypertension
7%
Nausea
7%
Rash
100%
80%
60%
40%
20%
0%
Study treatment Arm
B/F/TAF

BEST-HBV Trial Design

1Treatment groups
Experimental Treatment
Group I: B/F/TAFExperimental Treatment1 Intervention
Treatment group (1-arm study)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
B/F/TAF
2016
Completed Phase 4
~4900

Find a Location

Who is running the clinical trial?

Gilead SciencesIndustry Sponsor
1,082 Previous Clinical Trials
842,813 Total Patients Enrolled
University of Maryland, BaltimoreLead Sponsor
687 Previous Clinical Trials
374,618 Total Patients Enrolled
Joel V Chua, MDPrincipal InvestigatorInstitute of Human Virology, University of Maryland
1 Previous Clinical Trials
21 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies left for participants in this medical experiment?

"According to the information posted on clinicaltrials.gov, this medical study has concluded its patient recruitment as it was last updated on July 13th 2022. Nevertheless, there are still 491 other active trials in need of participants at present time."

Answered by AI

What medical conditions commonly respond to treatment with B/F/TAF?

"B/F/TAF is an anti-retroviral medication prescribed for a range of illnesses, including HIV 1 and those lacking resistance to darunavir. This drug can also be used as a first line treatment option in many cases."

Answered by AI

Has the Food and Drug Administration (FDA) accepted B/F/TAF as a legitimate medication?

"There is existing evidence demonstrating the safety of B/F/TAF, thus it has been assigned a rating of 3. This Phase 4 trial implies that this treatment has already achieved regulatory approval."

Answered by AI

How many participants are experiencing the benefits of this experiment?

"This study has already ceased to search for participants, with the initial post date being April 30th 2019 and final update occurring on July 13th 2022. For those interested in other clinical trials, 393 studies are actively searching for patients affected by hepatitis b while 98 researches seek volunteers infected with B/F/TAF."

Answered by AI

Are there any other exploratory studies that have utilized B/F/TAF?

"Initially studied at University of Zurich in 2002, B/F/TAF has since been researched extensively with 358 studies being concluded and 98 more currently underway. Philadelphia, Pennsylvania is a major hub for these live clinical trials."

Answered by AI

What are the main goals that this experiment seeks to achieve?

"This trial's main evaluation point is the participants' HIV-1 RNA levels taken 24 weeks into the study. Secondary assessments include a comparison of ALT normalization at Week 24, HBeAg loss by Week 48, and again measuring for ALT regularity after 48 weeks."

Answered by AI
~5 spots leftby Apr 2025