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Local Anesthetic

Liposomal bupivacaine for Cesarean Section Complications (OBLiBupi Trial)

Phase 4
Waitlist Available
Led By Kathleen M Antony, MD, MSCI
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 12, 24, 72 hours postpartum and entire hospital stay
Awards & highlights

OBLiBupi Trial Summary

This trial is testing if adding a certain type of painkiller to another type of painkiller given during surgery can reduce the amount of opioids needed in the first 48 hours after surgery.

Eligible Conditions
  • Cesarean Section Complications
  • Pain
  • Opioid Use Disorder

OBLiBupi Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at birth
This trial's timeline: 3 weeks for screening, Varies for treatment, and at birth for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total Opioid Usage in Oral Morphine Equivalents
Secondary outcome measures
Incidence of Opioid Side Effects
Maximum Post-operative Pain Scores Measured on NRS
Median Post-operative Pain Scores Measured on NRS
+4 more
Other outcome measures
6 Week Postpartum Satisfaction Survey Response Percentage
Amount of Opioid Prescribed at Discharge
Fetal Weight
+10 more

OBLiBupi Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Intervention: liposomal bupivacaineExperimental Treatment3 Interventions
The intervention arm will receive 30 mL of bupivacaine HCl plus 30 mL of saline plus 20 mL of liposomal bupivacaine injected into the lateral transversus abdominis plane via surgical approach (abdominal approach).
Group II: control armPlacebo Group2 Interventions
The control arm will receive 30 mL of bupivacaine HCl plus 50 mL of saline injected into the lateral transversus abdominis plane via surgical approach (abdominal approach).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine
FDA approved
Bupivacaine
FDA approved

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,183 Previous Clinical Trials
3,167,527 Total Patients Enrolled
UnityPoint Health-Meriter FoundationUNKNOWN
1 Previous Clinical Trials
140 Total Patients Enrolled
UnityPoint Health-MeriterUNKNOWN
1 Previous Clinical Trials
180 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the FDA cleared Liposomal bupivacaine for use?

"Since Liposomal bupivacaine is a phase 4 trial, meaning that the treatment has been approved, our team at Power estimates its safety to be a 3."

Answered by AI

How many people are volunteering to participate in this test?

"Recruitment for this study has concluded. The trial was first posted on October 11th, 2021 and last updated on October 28th, 2022. However, there are 538 other trials seeking participants who suffer from pain and 124 trials for Liposomal bupivacaine that are still recruiting patients."

Answered by AI

What types of pain does Liposomal bupivacaine help manage?

"Liposomal bupivacaine is most often used to treat permphigus. It can also be used to treat conditions like acute nonspecific tenosynovitis, general anesthesia, and lupus erythematosus cell."

Answered by AI

Could you please provide information on how to enroll in the trial?

"This study, which was last updated on October 28th, 2022 is not looking for new participants according to the listing on clinicaltrials.gov. However, there are 662 other trials that are currently open for enrollment"

Answered by AI

Are there other examples in the medical literature of successful use of Liposomal bupivacaine?

"Currently, 124 ongoing studies for Liposomal bupivacaine exist with 21 of them in Phase 3 trials. Most investigations are based out of Philadelphia but there are 169 different locations running these tests."

Answered by AI

Who else is applying?

What state do they live in?
Wisconsin
How old are they?
18 - 65
What site did they apply to?
Unity-Point Health Meriter
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

What questions have other patients asked about this trial?

How long does screening take?
PatientReceived no prior treatments

Why did patients apply to this trial?

Recent research and studies
clinicaltrials.govStudy
Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control
2021. "Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04897841.
~17 spots leftby Apr 2025
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