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Vitamin

Nicotinamide Riboside for Healthy Subjects

Phase 4
Waitlist Available
Led By Dost Ongur, MD PhD
Research Sponsored by Mclean Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and after 15 days of supplement use
Awards & highlights

Study Summary

This trial will investigate whether exogenous nicotinamide riboside (NR) supplementation can increase the NAD+/NADH ratio in the brain and improve bioenergetics functions in healthy individuals.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and after 15 days of supplement use
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and after 15 days of supplement use for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change From Baseline to the End of Treatment in Brain NAD+/NADH Ratio
Secondary outcome measures
Change From Baseline to the End of Treatment in Brain Creatine Kinase (CK) Enzyme Rate
Change From Baseline to the End of Treatment in Brain Phosphocreatine (PCr) to Adenosine Triphosphate (ATP) Ratio (PCr/ATP)
Change From Baseline to the End of Treatment in Muscle Creatine Kinase (CK) Enzyme Rate
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Nicotinamide riboside 2g/dayExperimental Treatment1 Intervention
Participants will receive NR at a dose of 2g/day
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nicotinamide Riboside
2022
N/A
~160

Find a Location

Who is running the clinical trial?

Mclean HospitalLead Sponsor
213 Previous Clinical Trials
21,683 Total Patients Enrolled
Dost Ongur, MD PhDPrincipal Investigator - Mclean Hospital
McLean Hospital
Umdnj-Robt W Johnson Medical Sch (Medical School)
Mass Gen Hospital (Residency)
3 Previous Clinical Trials
414 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Massachusetts
How old are they?
18 - 65
What site did they apply to?
McLean Hospital
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics
Dost Ongur 2017. "The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03151707.
~1 spots leftby Apr 2025
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