Sterilized probiotic LfQi601 for Dry Skin

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Dermatology Associates of Tallahassee, Tallahassee, FL
Dry Skin
Sterilized probiotic LfQi601 - Other
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a probiotic can improve skin health in adults with dry skin.

See full description

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Sterilized probiotic LfQi601 will improve 2 primary outcomes and 5 secondary outcomes in patients with Dry Skin. Measurement will happen over the course of Study Days 1, 28.

Day 1
Change in Dryness Self Assessment (D-VAS) over study days 1, 14, 28 and 35
Change in Itchiness Self Assessment (I-VAS) over study days 1, 14, 28 and 35
Change in Skindex16 Quality of Life over study days 1, 14, 28, 35
Corneometer Measurements
Tewameter Measurements
Study Days 1, 28
Change in Dry Skin Area and Severity Index (DASI) between study days 1 and 28
Skin microbiome analysis

Trial Safety

Trial Design

2 Treatment Groups

Sterilized probiotic (LfQi601)
1 of 2
Gel control product
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 50 total participants across 2 different treatment groups

This trial involves 2 different treatments. Sterilized Probiotic LfQi601 is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Sterilized probiotic (LfQi601)
Other
Sterilized probiotic topically administered.
Gel control product
Other
Inactive placebo.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: study days 1, 14, 28, 35
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly study days 1, 14, 28, 35 for reporting.

Who is running the study

Principal Investigator
E. B.
Eva Berkes, Principal Investigator
Florida State University

Closest Location

Dermatology Associates of Tallahassee - Tallahassee, FL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Provision of a signed and dated informed consent form
Stated willingness to comply with all study procedures and availability to attend study visits for the duration of the study
English-speaking
18-90 years of age
Score of a 2 or higher in one of the four areas assessed on the Dry Skin Area and Severity Index (DASI)

Patient Q&A Section

How many people get dry skin a year in the United States?

"Around 1.7 million US Americans experience severe or disabling cases of dry skin. In contrast with the USA population in general, Blacks are more likely to experience dry skin. A significant proportion of the population have had severe dry skin problems across a number of sub-groups (women, seniors, people with chronic illnesses, people who have been exposed to sun)." - Anonymous Online Contributor

Unverified Answer

What are common treatments for dry skin?

"Dry skin is a [disease|multifactorial disease]] that results from various genetic, environmental, and hormonal factors. There are dozens of different treatments to treat this disease. [The guideline of the European Academy of Dermatology] states that [good lifestyle choices] are important and that is what is most rewarding to patients. If treatments do help dry skin, [it's better for patients|it's better if you take it] only if it is [professionally] done by qualified professionals." - Anonymous Online Contributor

Unverified Answer

What are the signs of dry skin?

"Approximately 15% of adults report dry skin. The most common symptoms are itching and cracking or flaking of the skin. Other symptoms can include redness, scaly skin, chapped and scaly lips, and a dry nose bridge, but are generally not present for long periods. As the dryness increases, so does the burning and tingling sensations. Symptoms of dry skin can be treated by using moisturizers like salicylic acid or retinol creams applied daily. However, some individuals use topical corticosteroids, which may be effective in long term, or long acting topical corticosteroids taken daily for long periods of time during the summer and fall months." - Anonymous Online Contributor

Unverified Answer

What is dry skin?

"Dry skin is a mild chronic skin disease that consists of the breakdown on the skin epithelium. People with dry skin disease have more than just a dull-greyish or yellowish complexion. In addition to aesthetic concerns, they often have a diminished sense of health and vitality." - Anonymous Online Contributor

Unverified Answer

What causes dry skin?

"Causes of dry skin can be categorised into three broad groups: physiological, psychosocial and disease. Most causes are physiological and/or chronic. We propose the term "atopic dermatitis syndrome" to recognise that dry skin has several possible causes and that their interactions are complex and many factors can contribute, so cure is not necessarily inevitable." - Anonymous Online Contributor

Unverified Answer

Can dry skin be cured?

"Findings from a recent study, the cure rate in two groups of patients was statistically significantly lower after only the use of topical retinol compared with no treatment. There was no statistical correlation between clinical parameters and the improvement of dry skin." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of dry skin?

"Of 584 patients with symptomatic skin dryness the most frequent cause (26.9%) was autoimmune. Of 355 patients with dry skin by phototesting, most of these cases were primary, (80.2%). Of patients who had a positive photopatch, the most common diagnoses were mild to moderate atopic dermatitis (37.0%), irritant contact dermatitis (29.5%), eczema fulminans (14.8%), and atopic dermatitis (7.5%). Photoprotective use by the patients was fairly uncommon, only 37.3% prescribed a sunblock, and sun protective clothing was seldom recommended." - Anonymous Online Contributor

Unverified Answer

How does sterilized probiotic lfqi601 work?

"Lactobacillus plantarum is a natural food supplement. The lfqi601 was administered to patients with chronic obstructive pulmonary disease prior to the patients’ inhalation therapy. In a recent study, findings suggested that Lactobacillus plantarum could be implemented as an effective probiotic nutritional supplement that alleviates both symptoms of the disease and improves the quality of life of patients with respiratory symptoms, alleviating the negative effects of the disease." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of sterilized probiotic lfqi601?

"The incidence rates of six key adverse events of sterilized L fqi601 tablets for oral administration at the doses and schedules adopted in the clinical trial of the product are within an acceptable range and comparable to that reported in related clinical studies performed at L fqi601 manufacturers facility over a wide period of time. L fqi601 is generally well accepted (in terms of adverse events) and its use is convenient for patients with chronic diseases with mild or moderate symptoms. The safety and efficacy of L fqi601 will be further established in a double-blind randomized trial." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for dry skin?

"Patient and clinician preferences, and evidence from recent trials, suggest that patients with dry skin may be more favorable to clinical trials. Patient preferences were driven by an assumption that dry skin is a marker for the underlying condition. In a recent study, findings provide an important starting point for the design of clinical trials in patients with dry skin." - Anonymous Online Contributor

Unverified Answer

What is the latest research for dry skin?

"The research was of [low quality], but the research was not [inconsistent]. This is an area of further research, and it is also an area that could potentially be [redeemed]." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in sterilized probiotic lfqi601 for therapeutic use?

"Therapeutic usage of Lfqi601, can improve skin inflammation, dry skin/atopic dermatitis(AD), photoaging/ photoageing and UV damage(UVR). The data collected so far (in vitro, clinical and in vivo, all demonstrate the efficacy of this bioactive formulation in photoaging and skin aging." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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