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carvedilol for Post-Traumatic Stress Disorder

Phase 2
Waitlist Available
Research Sponsored by Columbia Northwest Pharmaceuticals
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Study Summary

The investigators hypothesize that carvedilol, at less then therapeutic doses for cardiac effect, will reduce symptoms of Post Traumatic Stress Disorder.

Eligible Conditions
  • Post-Traumatic Stress Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Davidson Trauma Scale (DTS)
Secondary outcome measures
Clinician Administered PTSD Scale (CAPS)
Insomnia Severity Index (ISI)

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: carvedilolActive Control1 Intervention
Patients randomized to carvedilol will be administered doses ranging from 6.25 to 15.625 mg/day using a flexible-dosing model. After a 1 week titration, investigators my increase daily dose by 6.25 mg/day at weeks 1 and 2 for a maximum dose of 15.625 mg/day. Weeks 3-4 will patients will remain on a stable, tolerable dose. At week 5 patients will have a 1 week taper.
Group II: Sugar PillPlacebo Group1 Intervention
Patients randomized to placebo will follow same dosing guidelines as if they were in the active comparator arm, carvedilol.

Find a Location

Who is running the clinical trial?

Columbia Northwest PharmaceuticalsLead Sponsor
1 Previous Clinical Trials
80 Total Patients Enrolled
Arifulla Khan, MDStudy DirectorColumbia Northwest Pharmaceuticals, LLC
1 Previous Clinical Trials
80 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)
2010. "Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01221792.
All > Trauma
~6 spots leftby Apr 2025
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