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Transcranial Magnetic Stimulation
TMS for Psychosis
N/A
Recruiting
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights
Study Summary
This trial uses noninvasive TMS & MRI to study brain activity in people with early psychosis, to understand how memory works.
Who is the study for?
This trial is for individuals within the first ten years of experiencing psychotic symptoms, diagnosed with conditions like schizophrenia, schizoaffective disorder, or bipolar with psychosis. Participants must be able to understand and agree to the study's procedures.Check my eligibility
What is being tested?
The study is testing how working memory functions in early psychosis patients using Transcranial Magnetic Stimulation (TMS) alongside brain imaging. TMS uses magnetic fields on the scalp to influence brain activity noninvasively.See study design
What are the potential side effects?
TMS may cause discomfort at the site of application, headaches, lightheadedness, or seizures in rare cases. It's generally considered safe but can have different effects depending on individual sensitivity.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Reaction time during working memory
Resting state functional connectivity between the left inferior parietal lobule and the regions of the frontoparietal control network
Resting state functional connectivity within the default mode network
+1 moreTrial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active TMSExperimental Treatment1 Intervention
Participants will receive single-session administration of TMS. Functional MRI will be acquired before and immediately after the intervention.
Group II: Placebo TMSPlacebo Group1 Intervention
Participants will also receive single session administration of placebo TMS (at least two days apart from the day of the active TMS). Functional MRI will be acquired before and immediately after the intervention.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active TMS
2017
N/A
~50
Find a Location
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,935 Previous Clinical Trials
13,198,621 Total Patients Enrolled
3 Trials studying Psychosis
731 Patients Enrolled for Psychosis
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I was diagnosed with a psychotic disorder within the first 10 years of showing symptoms.I do not have any unstable illnesses that would stop me from participating in the study.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Research Study Groups:
This trial has the following groups:- Group 1: Active TMS
- Group 2: Placebo TMS
Awards:
This trial has 0 awards, including:Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does this experiment accommodate elderly participants?
"According to the study's eligibility rules, participants between 18 and 35 years of age are welcome to apply."
Answered by AI
Am I eligible to join the trial cohort?
"Qualified participants for this trial must possess a diagnosis of psychosis and be between 18 and 35 years old. For the purposes of the study, 20 individuals are needed to fulfil its requirements."
Answered by AI
Are there any openings for participants in this experiment?
"On clinicaltrials.gov, this medical trial is readily seeking patients with relevant symptoms. It was first made public on April 4th 2023 and last updated a month later on May 4th of the same year."
Answered by AI
To what extent has this medical trial been populated with participants?
"Affirmative. Per the information on clinicaltrials.gov, this trial is actively enrolling participants at 1 location and seeking 20 patients in total. It was first posted on April 4th 2023 and last updated May 4th 2023."
Answered by AI
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