MyCancerGene for Genetic Predisposition

Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA
Genetic Predisposition+1 More ConditionsMyCancerGene - Behavioral
All Sexes

Study Summary

This trial will test whether a patient-centered genetic app can increase understanding of, and affective and behavioral responses to, genetic testing. The study hypothesis is that the intervention will be associated with increases in knowledge, decreases in distress, increases in communication with relatives and health care providers, and increases in performance of risk reducing health behaviors.

Eligible Conditions
  • Genetic Predisposition
  • Cancer

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3

Study Objectives

2 Primary · 7 Secondary · Reporting Duration: Baseline - 18 months

Baseline - 18 Months
Multi-dimensional Impact of Cancer Risk Assessment Questionnaire (MICRA)
Patient Reported Outcomes Measurement Information System (PROMIS)
The KnowGene Scale
Baseline - 18 months
Behavioral Risk Factor Surveillance System Questionnaire (BRFSS)
Health and Diet Survey Dietary Guidelines Supplement
Impact of Events Scale (IES)
Perceptions of Genetic Disease
Sharing Genomic Information with Relatives (adapted from the PHENX Toolkit)
Test Result Recall

Trial Safety

Phase-Based Safety

1 of 3

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

Usual Care Group
1 of 2
Intervention Group
1 of 2

Active Control

Experimental Treatment

400 Total Participants · 2 Treatment Groups

Primary Treatment: MyCancerGene · No Placebo Group · N/A

Intervention Group
Experimental Group · 1 Intervention: MyCancerGene · Intervention Types: Behavioral
Usual Care GroupNoIntervention Group · 1 Intervention: Usual Care Group · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline - 18 months

Who is running the clinical trial?

Abramson Cancer Center at Penn MedicineLead Sponsor
358 Previous Clinical Trials
106,854 Total Patients Enrolled
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,404 Total Patients Enrolled
American Cancer Society, Inc.OTHER
216 Previous Clinical Trials
97,973 Total Patients Enrolled
Angela R Bradbury, MDPrincipal InvestigatorUniversity of Pennsylvania
2 Previous Clinical Trials
1,613 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Both males and females can participate.
You must be able to speak English.
You need to have access to the internet and/or a mobile device.

Who else is applying?

What state do they live in?
How old are they?
18 - 65100.0%
What site did they apply to?
Abramson Cancer Center at the University of Pennsylvania100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

How responsive is this trial?

Typically responds via

Frequently Asked Questions

What are the intended outcomes of this research?

"This trial has two primary objectives: to evaluate patients using the KnowGene Scale, and to measure changes in uncertainty with the Multi-dimensional Impact of Cancer Risk Assessment Questionnaire (MICRA). Secondary evaluation includes assessing shifts in perceived risk, timeline and utility through quantitative scales as well as Yes/No responses for dietary guidelines. The study will span a period of 18 months from baseline." - Anonymous Online Contributor

Unverified Answer

Are there any vacancies available for participants in this trial?

"According to details provided on, this study is currently enrolling participants. Initially published on May 3rd 2021, the trial was most recently updated July 11th 2022." - Anonymous Online Contributor

Unverified Answer

How many participants is the medical trial accepting at this time?

"Affirmative, has evidence that this research trial is actively recruiting participants. It was initially posted on May 3rd 2021 and the last update occured on July 11th 2022. 400 individuals must be admitted at a single medical centre to meet their recruitment goals." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.