Study Summary
This trial proposes the use of ketamine to relieve suicidal thoughts in depressed patients within hours of treatment. If successful, this would be a scalable intervention for busy emergency clinicians to implement.
- Suicidal Thoughts
- Major Depressive Disorder
- Depression, Bipolar Disorder
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: 24 hours post-treatment
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
2 Treatment Groups
midazolam
1 of 2
Ketamine
1 of 2
Active Control
Experimental Treatment
90 Total Participants · 2 Treatment Groups
Primary Treatment: Ketamine hydrochloride injection · No Placebo Group · Phase 4
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 65 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| New Mexico | 50.0% |
| Rhode Island | 25.0% |
| New York | 25.0% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Comprehensive Psychiatric Emergency Department of Columbia University Medical Center | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
How many prior treatments have patients received?
| 3+ | 100.0% |
Frequently Asked Questions
Are there any remaining openings to join this medical experiment?
"Indeed, clinicaltrials.gov corroborates that patient recruitment is underway for this trial which was first published on February 1st 2021 and last updated on March 8th 2022; with the objective of sourcing 90 participants from a single medical centre." - Anonymous Online Contributor
Has the FDA granted authorization for Ketamine hydrochloride injection?
"Due to its approval status as a Phase 4 trial, Ketamine hydrochloride injection was assigned the maximum safety rating of 3." - Anonymous Online Contributor
Do I qualify to partake in this medical experiment?
"This trial is seeking 90 individuals, aged 18 to 65 with suicidal ideation who have recently checked into an emergency department and been diagnosed by a psychiatrist. Additionally, they must present with a DSM5 major depressive episode (unipolar or bipolar), score 4+ on the Beck Scale for Suicidal Ideation assessment, and agree to voluntary psychiatric hospitalization." - Anonymous Online Contributor
Does this trial include subjects who are of advanced age?
"The trial's eligibility criteria specify that the minimum age of participants is 18 and any patient over 65 won't be accepted." - Anonymous Online Contributor
To what afflictions is Ketamine hydrochloride injection typically administered?
"Ketamine hydrochloride injection is traditionally used to treat seizures and epilepsy, yet can also be deployed to manage conditions such as amnesia, therapeutic procedure-related pain, and epileptic episodes." - Anonymous Online Contributor
How many people have been admitted to partake in this experiment?
"Confirmed. The clinical trial listing on clinicialtrials.gov reveals that this medical research is currently recruiting participants, with an initial post date of January 2nd 2021 and last update occurring March 8th 2022. 90 individuals are required to be enrolled at a single centre for the study to proceed as planned." - Anonymous Online Contributor