Skincare Regimen for Postinflammatory Hyperpigmentation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a skincare routine to determine its effectiveness in reducing post-inflammatory hyperpigmentation (dark spots following skin inflammation) in individuals with darker skin tones. Participants will use a special peel, the Pigment Balancing Peel, containing ingredients like glycolic acid and vitamin C, followed by a daily regimen that includes a cleanser, serum, gel, and sunscreen. The trial seeks individuals who are not Caucasian, have been diagnosed with post-inflammatory hyperpigmentation, and are willing to follow the study instructions for 12 weeks. As an unphased trial, this study offers a unique opportunity to contribute to skincare research and potentially improve treatment options for hyperpigmentation.
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are using any skin treatments that might interfere with the study, you may need to stop those.
What prior data suggests that this skincare regimen is safe for reducing postinflammatory hyperpigmentation?
A previous study found that gentle skin peels, such as the Pigment Balancing Peel, are safe for all skin types, including darker tones. The peel contains glycolic acid and kojic acid, long-used in skincare. These ingredients help even out skin tone and are generally well-tolerated.
Some individuals might experience mild side effects, like redness or slight irritation, but these typically resolve quickly. The studies available reported no serious side effects, suggesting the treatment is safe when used as directed.12345Why are researchers excited about this trial?
Unlike standard treatments for postinflammatory hyperpigmentation, which often rely on single methods like topical creams or chemical peels, the Pigment Balancing Peel regimen combines multiple approaches for a comprehensive effect. It pairs a potent peel with a specialized post-peel regimen, including a Discoloration Defense Serum and a Brightening UV Defense Sunscreen, to not only address pigmentation but also prevent further skin damage. Researchers are excited because this multi-step approach targets discoloration from several angles, potentially enhancing effectiveness and skin health compared to existing single-treatment options.
What evidence suggests that this skincare regimen is effective for postinflammatory hyperpigmentation?
Studies have shown that the Pigment Balancing Peel, which participants in this trial will receive, effectively reduces dark spots on the skin that appear after inflammation, especially in people with darker skin tones. Research indicates that combining chemical peels like this one with skin-lightening products can significantly improve uneven skin color. A similar new peel received high satisfaction ratings from patients and posed a low risk of side effects. Most participants using chemical peels experienced some improvement in their dark spots. This treatment targets stubborn skin discoloration and helps create a more even skin tone.678910
Who Is on the Research Team?
Jared Jagdeo, MD MS
Principal Investigator
SUNY Downstate Health Sciences University Department of Dermatology
Are You a Good Fit for This Trial?
This trial is for non-Caucasian men and women over 18 with skin types IV-VI who have post-inflammatory hyperpigmentation. Participants must be willing to follow the study's instructions and attend all visits, not be pregnant or lactating, nor participating in other clinical studies.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the SkinCeuticals comprehensive skin care regimen, including the Pigment Balancing Peel and a regimen of Hydrating B5 Gel, Discoloration Defense, LHA Cleansing Gel, and Brightening UV Defense sunscreen
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Daily Brightening Sunscreen
- Discoloration Defense Serum
- Hydrating B5 Gel
- LHA Cleansing Gel
- Pigment Balancing Peel
Trial Overview
The trial tests a SkinCeuticals regimen including Pigment Balancing Peel and supplementary products (Discoloration Defense Serum, LHA Cleansing Gel, Hydrating B5 Gel, Daily Brightening Sunscreen) over 12 weeks to reduce hyperpigmentation in skin of color.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Discoloration Defense Serum: Applied twice daily (morning and night) LHA Cleansing Gel: Used twice daily (AM and PM) to cleanse the skin and target discoloration. Hydrating B5 Gel: Applied throughout the day to hydrate the skin. Brightening UV Defense Sunscreen: Used throughout the day.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Narrows Institute for Biomedical Research
Lead Sponsor
L'Oreal
Industry Sponsor
Citations
A Novel Peel to Prevent Post‐Inflammatory ...
The novel peel is an effective method for minimizing PIH, with high patient satisfaction, low adverse outcomes, and no requirement for ...
View of Acne-induced Post-inflammatory Hyperpigmentation
This article provides for the first time an easy-to-use scoring tool and an easy-to-follow treatment algorithm developed for acneinduced post-inflammatory ...
Treatment of Post-Inflammatory Hyperpigmentation in Skin ...
Chemical peels (9%) and hydroquinone (7%) were among other treatments with less effective outcomes. PIH and its persistence is a prevalent issue, significantly ...
4.
researchgate.net
researchgate.net/publication/382678429_Treatment_of_Post-Inflammatory_Hyperpigmentation_in_Skin_of_Colour_A_Systematic_ReviewTreatment of Post-Inflammatory Hyperpigmentation in Skin ...
Partial improvement was seen in 85% and 66% of participants, respectively. Laser was the only intervention that offered complete resolution in a ...
Consensus on management of acne-induced post- ...
Chemical peels used alone or in combination with lightening agents can be effective in all skin types, more commonly in patients with darker ...
A Novel Regimen for Treatment and Prevention of Post ...
The comprehensive regimen features the Pigment Balancing Peel which combines glycolic acid, lactic acid, kojic acid, vitamin C, and emblica into a treatment ...
Evidence and Considerations in the Application of Chemical ...
Due to the increased risk of prolonged or permanent pigmentary changes, deep peels are not recommended for most dark-skinned individuals. Currently, new laser ...
Evaluation of Safety and Efficacy of Chemical Peels With ...
This study aims to assess the effects of topical chemical peels of different concentrations and pH, applied manually and with ultrasounds, on the level of ...
9.
dermatologytimes.com
dermatologytimes.com/view/integrating-chemical-peels-and-addressing-real-world-barriers-in-melasmaIntegrating Chemical Peels and Addressing Real-World ...
Superficial peels can be safely utilized across all skin types, from the lightest to the most heavily pigmented patients. When superficial ...
A Novel Peel to Prevent Post-Inflammatory ...
Studies show that a 20% azelaic acid cream significantly reduces pigmentation, and when combined with 15%–20% glycolic acid, its efficacy in ...
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