Topical PUVA for Vitiligo

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
VitiligoPhototherapy - Device
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether a new treatment, narrow band ultraviolet B (NB-UVB) is better than the current standard treatment, psoralen with long wavelength ultraviolet A radiation (PUVA), for hand psoriasis/eczema.

Eligible Conditions
  • Vitiligo

Treatment Effectiveness

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Every four weeks up to 16 weeks, and at 24 weeks

Week 24
The primary endpoint will be based on the change in visual cutaneous symptoms as measured by the modified ASI score
Week 16
Adverse effects will be assessed every four weeks, including erythema, pruritus, and tanning. This will be assessed using the following scale: 0=none, 1=mild, 2=moderate, 3=severe.
Week 24
Hand

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Topical PUVA
1 of 2
NB-UVB
1 of 2

Active Control

30 Total Participants · 2 Treatment Groups

Primary Treatment: Topical PUVA · No Placebo Group · Phase 2

Topical PUVA
Device
ActiveComparator Group · 1 Intervention: Phototherapy · Intervention Types: Device
NB-UVB
Device
ActiveComparator Group · 1 Intervention: Phototherapy · Intervention Types: Device

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: every four weeks up to 16 weeks, and at 24 weeks

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,325 Previous Clinical Trials
1,534,063 Total Patients Enrolled
4 Trials studying Vitiligo
95 Patients Enrolled for Vitiligo
Harvey Lui, MD, FRCPCPrincipal InvestigatorUniversity of British Columbia
3 Previous Clinical Trials
50 Total Patients Enrolled
3 Trials studying Vitiligo
50 Patients Enrolled for Vitiligo

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Individuals with chronic, symmetrical, severe hand psoriasis and eczema are those who have not responded to topical corticosteroid treatments
Subjects must be 18 years old or older.

Who else is applying?

What state do they live in?
Tennessee100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
The Skin Care Center, Vancouver General Hospital100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%