← Back to Search

Monoclonal Antibodies

dupilumab for Asthma

Phase 3
Waitlist Available
Led By Parameswaran Nair, MD, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up between screening (week -4) and week 16.
Awards & highlights

Study Summary

This study is evaluating whether a drug called Dupilumab can improve asthma control and reduce airway inflammation in people with asthma and a "T2 immune signature".

Eligible Conditions
  • Asthma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~between screening (week -4) and week 16.
This trial's timeline: 3 weeks for screening, Varies for treatment, and between screening (week -4) and week 16. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Proportion of patients that achieve at least one doubling dose improvement in PC20 methacholine and/or a 50% reduction in FEV1 reversibility after bronchodilator.
Secondary outcome measures
Change in Asthma Control Questionnaire-5 (ACQ-5)
Change in Asthma Control Questionnaire-5 (AQLQ)
Change in Asthma Control Test (ACT)
+6 more
Other outcome measures
Change in CT airway remodeling and airway mucus scores (n=12 in each arm).
Change in MRI ventilation heterogeneity (n=12 in each arm).

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: dupilumabActive Control1 Intervention
Dupilumab 300 mg subcutaneously (SC) every 2 weeks as an investigational drug. For those randomized to dupilumab, a loading dose of 600 mg will be given only at randomization/Visit 2. Sterile dupilumab of will be provided in 150 mg/mL in glass prefilled syringes (2.25 mL total volume) to deliver 300 mg in 2 mL.
Group II: matched placeboPlacebo Group1 Intervention
Sterile placebo for dupilumab will be provided in identically matched glass prefilled syringes to deliver 2 mL.

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
881 Previous Clinical Trials
2,597,866 Total Patients Enrolled
19 Trials studying Asthma
895 Patients Enrolled for Asthma
SanofiIndustry Sponsor
2,164 Previous Clinical Trials
3,514,956 Total Patients Enrolled
46 Trials studying Asthma
27,314 Patients Enrolled for Asthma
Parameswaran Nair, MD, PhDPrincipal InvestigatorMcMaster University
7 Previous Clinical Trials
233 Total Patients Enrolled
4 Trials studying Asthma
87 Patients Enrolled for Asthma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Journal of Magnetic Resonance ImagingJournal
Hyperpolarized<sup>3</sup>he And<sup>129</sup>xe MRI: Differences in Asthma Before Bronchodilation
Svenningsen, Sarah, Miranda Kirby, Danielle Starr, Del Leary, Andrew Wheatley, Geoffrey N. Maksym, David G. McCormack, and Grace Parraga. 2013. “Hyperpolarized3he And129xe MRI: Differences in Asthma Before Bronchodilation”. Journal of Magnetic Resonance Imaging. Wiley. doi:10.1002/jmri.24111.
American Journal of Respiratory and Critical Care MedicineJournal
Guidelines for Methacholine and Exercise Challenge Testing—1999
“Guidelines for Methacholine and Exercise Challenge Testing—1999”. 2000. “Guidelines for Methacholine and Exercise Challenge Testing—1999”. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society. doi:10.1164/ajrccm.161.1.ats11-99.
clinicaltrials.govStudy
Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.
2019. "Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03884842.
~4 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top