Study Summary
This trial is testing ketoconazole as a possible treatment for brain tumors. Ketoconazole is an antifungal drug that may be able to block a protein, tGLI1 and may help to treat brain tumors.
- Breast Cancer Metastatic to the Brain
- Astrocytoma
- Oligodendroglioma
- Stage IV Breast Cancer
- Brain Tumor
- Breast Cancer
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 3 Secondary · Reporting Duration: Up to 30 days after surgery
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Arm II (standard surgery)
1 of 2
Arm I (ketoconazole)
1 of 2
Active Control
Experimental Treatment
19 Total Participants · 2 Treatment Groups
Primary Treatment: Ketoconazole · No Placebo Group · Phase < 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 4 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
To what extent has Ketoconazole been tested in other medical trials?
"Presently, 10 research trials for Ketoconazole are ongoing. Of these initiatives, one is in its advanced Phase 3 phase. While the majority of studies occur in Rochester, Minnesota, there are 28 total sites conducting experiments with this treatment." - Anonymous Online Contributor
Is there an ongoing recruitment process for participants in this experiment?
"Affirmative. Clinicaltrials.gov documents this clinical trial as currently recruiting participants, which began on March 13th 2019 and was most recently modified on October 6th 2022. A total of 19 patients are needed to complete the study at one medical site." - Anonymous Online Contributor
Has this investigation ever been conducted before?
"Presently, 10 clinical trials involving Ketoconazole are taking place in 23 cities spread across 3 nations. The initial trial for this medication was launched by Sanofi back in 2004 and featured 20 patients; the drug approval process concluded at that time. Since then, 121 additional studies have been completed." - Anonymous Online Contributor
What medical ailments does Ketoconazole typically address?
"Ketoconazole is the primary drug used to fight coccidioidomycosis, although it can be helpful in warding off other illnesses like paracoccidioidomycosis and tinea corporis caused by trichophyton mentagrophytes. It may also provide assistance with chromomycosis." - Anonymous Online Contributor
What is the current enrollment rate for participants in this trial?
"Affirmative, the clinical data posted on clinicaltrials.gov demonstrates that this medical investigation is actively searching for study participants. Initially posted on March 13th 2019 and most recently revised October 6th of 2022, 19 patients are needed to take part at 1 location." - Anonymous Online Contributor