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Hormone Therapy

prednisone 5 mg po BID for Prostate Cancer

Phase 2

Waitlist Available

Led By Susan Slovin, MD, PhD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

Study Summary

This trial is testing a new hormone therapy to see if it's effective against prostate cancer, with or without chemotherapy.

Eligible Conditions

Prostate Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

progression free survival (rPFS)

Secondary outcome measures

PSA progression free survival (PSA PFS)

objective response rate (ORR)

toxicity

Trial Design

2Treatment groups

Experimental Treatment

Group I: Cabazitaxel 25 mg/m2 IV + abiraterone acetate 1000 mg po dailyExperimental Treatment3 Interventions

Arm 2: Cabazitaxel 25 mg/m2 IV + abiraterone acetate 1000 mg po daily + prednisone 5 mg po BID

Group II: Abiraterone acetate 1000 mg po daily + prednisone 5 mg po BIDExperimental Treatment2 Interventions

Arm 1: Abiraterone acetate 1000 mg po daily + prednisone 5 mg po BID

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Abiraterone acetate 1000 mg po daily

2014

Completed Phase 2

~80

prednisone 5 mg po BID

2014

Completed Phase 2

~80

Cabazitaxel 25 mg/m2 IV

2014

Completed Phase 2

~80

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

SanofiIndustry Sponsor

2,164 Previous Clinical Trials

3,514,900 Total Patients Enrolled

47 Trials studying Prostate Cancer

6,361 Patients Enrolled for Prostate Cancer

Thomas Jefferson UniversityOTHER

445 Previous Clinical Trials

145,909 Total Patients Enrolled

6 Trials studying Prostate Cancer

1,446 Patients Enrolled for Prostate Cancer

Weill Medical College of Cornell UniversityOTHER

1,055 Previous Clinical Trials

1,316,215 Total Patients Enrolled

48 Trials studying Prostate Cancer

35,559 Patients Enrolled for Prostate Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What conditions are often treated with a regimen of prednisone 5 mg orally twice daily?

"Prednisone 5 mg taken orally twice a day can be leveraged to treat thyroiditis, ulcerative colitis and malignant neoplasms."

Answered by AI

What have past investigations revealed about the efficacy of prednisone 5 mg taken orally twice a day?

"Currently, there are 374 trials in progress assessing the effects of prednisone 5 mg po BID. Of these studies, 101 have progressed to Phase 3 status. While some clinical experiments involving this drug regime take place in Duarte, 17233 different global locations have participated in research surrounding prednisone 5 mg po BID."

Answered by AI

How many participants have signed up for the study thus far?

"The recruitment for this medical trial is no longer active, with the original posting date being August 1st 2014. An edit was made on November 1st 2022. If you are looking to join a study, there are 1315 trials recruiting patients with prostate cancer and 374 researching prednisone 5 mg po BID that require volunteers."

Answered by AI

Is there still availability for participation in this research endeavor?

"Unfortunately, at this moment in time, participants are not being accepted for this clinical trial. Having been initially posted on August 1st 2014 and last updated November 1st 2022, it is no longer active. However, there are 1315 studies open to those with prostate cancer and 374 trials that require daily dosing of prednisone 5 mg which remain actively recruiting patients."

Answered by AI

What potential adverse effects can be anticipated when taking 5mg of prednisone orally twice daily?

"The safety score of prednisone 5 mg po BID was evaluated as a 2, considering that no efficacy data is available yet and only limited evidence exists to support its risk profile."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Multicenter Trial of Abiraterone Acetate With or Without Cabazitaxel in Treatment of Metastatic Castration Resistant Prostate Cancer

2014. "Multicenter Trial of Abiraterone Acetate With or Without Cabazitaxel in Treatment of Metastatic Castration Resistant Prostate Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02218606.