Combination ophthalmic solution (LNZ101) dosed bilaterally for Constricted Pupil

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Site #302, Chandler, AZConstricted Pupil+3 MoreAceclidine Ophthalmic Solution - Drug
Eligibility
45 - 75
All Sexes
What conditions do you have?
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Study Summary

This trial studied the safety of a drug for long-term use to help with presbyopia (age-related vision problems).

Eligible Conditions
  • Near Vision
  • Constricted Pupil
  • Presbyopia
  • Eye Diseases

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: 7 visits over a total duration of approximately 28 weeks

Week 28
Primary Objective

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

3 Treatment Groups

Combination ophthalmic solution (LNZ101) dosed bilaterally
1 of 3
Aceclidine ophthalmic solution dosed bilaterally
1 of 3
Placebo (Vehicle) ophthalmic solution dosed bilaterally
1 of 3

Experimental Treatment

Non-Treatment Group

300 Total Participants · 3 Treatment Groups

Primary Treatment: Combination ophthalmic solution (LNZ101) dosed bilaterally · Has Placebo Group · Phase 3

Combination ophthalmic solution (LNZ101) dosed bilaterally
Drug
Experimental Group · 1 Intervention: Aceclidine+Brimonidine combination ophthalmic solution · Intervention Types: Drug
Aceclidine ophthalmic solution dosed bilaterally
Drug
Experimental Group · 1 Intervention: Aceclidine Ophthalmic Solution · Intervention Types: Drug
Placebo (Vehicle) ophthalmic solution dosed bilaterally
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aceclidine+Brimonidine combination ophthalmic solution
2022
Completed Phase 2
~120

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 7 visits over a total duration of approximately 28 weeks

Who is running the clinical trial?

LENZ Therapeutics, IncLead Sponsor
5 Previous Clinical Trials
797 Total Patients Enrolled
ORA, Inc.Industry Sponsor
60 Previous Clinical Trials
7,508 Total Patients Enrolled
Alisyn Facemire, BAStudy DirectorLENZ Therapeutics
3 Previous Clinical Trials
715 Total Patients Enrolled

Eligibility Criteria

Age 45 - 75 · All Participants · 5 Total Inclusion Criteria

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Frequently Asked Questions

Could I potentially participate in this clinical experiment?

"This trial seeks to enrol 300 participants aged between 45 and 75 years old with presbyopia." - Anonymous Online Contributor

Unverified Answer

Are applicants younger than 85 years of age being accepted into this research?

"The prerequisites for this experiment restrict the participants to being between 45 and 75 years of age. Additionally, there are 11 trials available for those below 18 and 117 options for individuals over 65." - Anonymous Online Contributor

Unverified Answer

Are any new volunteers being accepted for this research initiative?

"According to the information on clinicaltrials.gov, this medical investigation is actively recruiting participants. The study was first advertised on February 21st 2023 and has since been amended (most recently March 2nd 2023)." - Anonymous Online Contributor

Unverified Answer

How many participants have registered for this research endeavor?

"Affirmative. Per clinicaltrials.gov, this research venture is presently searching for volunteers; the study was originally posted on February 21st 2023 and refreshed lastly on March 2nd 2023. 300 people are expected to be enrolled at two distinct centres." - Anonymous Online Contributor

Unverified Answer

What side effects have been observed with the bilaterally administered Combination ophthalmic solution (LNZ101)?

"Our organisation has rated Combination ophthalmic solution (LNZ101) dosed bilaterally a 3 on the safety scale due to both efficacy evidence and numerous rounds of data supporting its security." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.