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Monoclonal Antibodies

Denosumab Q4W for Multiple Myeloma

Phase 2
Waitlist Available
Led By Elizabeth K O'Donnell, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial is testing a possible therapy for the effects of Multiple Myeloma on kidney function.

Eligible Conditions
  • Multiple Myeloma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent Change Of sCTX Levels
Secondary outcome measures
Percent Change In Bone Mineral Density
Percent Change In Bone Turnover Markers
Percent Change In uNTX Levels
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Denosumab InjectionExperimental Treatment1 Intervention
Patients will be administered Denosumab Q4W at a pre-determine dose for 12 cycles. Denosumab Q4W is administered by subcutaneous injection.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,300 Total Patients Enrolled
35 Trials studying Multiple Myeloma
2,613 Patients Enrolled for Multiple Myeloma
AmgenIndustry Sponsor
1,370 Previous Clinical Trials
1,377,633 Total Patients Enrolled
96 Trials studying Multiple Myeloma
20,685 Patients Enrolled for Multiple Myeloma
Emory UniversityOTHER
1,636 Previous Clinical Trials
2,560,518 Total Patients Enrolled
25 Trials studying Multiple Myeloma
1,923 Patients Enrolled for Multiple Myeloma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency
Elizabeth O'Donnell 2016. "A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02833610.
All > Myeloma
~6 spots leftby Apr 2025
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