vancomycin, magnesium citrate, microbiota for Pitt Hopkins Syndrome

"Vancomycin, magnesium citrate, and microbiota have all been studied for safety in Phase 2 trials. As such, Power rated them as having a level of security that is satisfactory but not yet fully established with the necessary evidence to ensure efficacy."

"According to the information present on clinicaltrials.gov, this trial is no longer searching for candidates; last edited in December 2021 and first posted in September 2019. Despite this, there are over 1500 other active trials that participants can join at any given time."

"This clinical trial has ceased recruitment, having been posted on September 30th 2019 and last updated December 29th 2021. Still, 1496 trials are in the process of enrolling patients with cholera infantum while 57 studies are looking for participants to investigate vancomycin, magnesium citrate, and microbiota."

"Vancomycin, magnesium citrate and microbiota can be effective treatments for clostridium difficile associated diarrhea (cdad), staphylococcal infections, as well as prophylaxis of migraine headaches."

"This trial seeks 7 candidates, aged between seven and seventeen, with a confirmed diagnosis of cholera infantum. It is also necessary for applicants to have been afflicted by GI issues for no less than two years without any change in treatments or diet over the past two months. Furthermore, they must be physically able to swallow pills unchewed as well as provide access to records from their last 24-month medical history for review by the study's physician"

"The age limitations for this trial are 7 years old at the youngest and 17 years old at the oldest."

"The main objective of this clinical trial, measured over a two-week period from baseline to week 14, is to analyse safety markers. Secondary objectives include Parent Global Impressions of Pitt Hopkins Syndrome symptoms (PGI-PTHS), rated on a scale from -3 (much worse) to +3 (much better); Clinical Global Impressions of GI Disorders severity rating on a 1-7 scale with 1 being normal and 7 being the worst; and Clinical Global Impressions of PTHS Symptoms severity ratings also ranging between 1 and 7."

"Currently, there are 57 active clinical trials for vancomycin, magnesium citrate and microbiota with 7 of these being in Phase 3. Seven of the observed studies take place in Jupiter, Florida whilst all 342 research sites across the nation explore potential uses for this medication."