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Sleep Deprivation for Depression

N/A
Recruiting
Led By Laura Lewis, PhD
Research Sponsored by Boston University Charles River Campus
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (approximately 1 month)
Awards & highlights

Study Summary

This trial looks at how sleep and mood are connected in people with depression and in healthy people. It uses MRI measures of brain function to see how neural systems are affected by sleep and sleep deprivation, and how these links relate to mood in depression.

Who is the study for?
This trial is for adults aged 18-80 with major depressive disorder. Participants must not have metal implants, be pregnant, or have a history of substance abuse in the last 6 months. They should weigh less than 250 pounds and not take medications affecting sleep or psychiatric function.Check my eligibility
What is being tested?
The study examines how sleep deprivation affects brain function related to mood in people with depression compared to healthy individuals. It uses MRI scans to observe changes in neural systems due to lack of sleep.See study design
What are the potential side effects?
Since this trial involves sleep deprivation as an intervention, side effects may include increased fatigue, irritability, cognitive impairments, and potential worsening of mood or depressive symptoms during the study period.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (approximately 1 month)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (approximately 1 month) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Montgomery-Asberg Depression Rating from baseline to post intervention
Change in cerebrospinal fluid (CSF) flow measurements from baseline to post intervention
Change in fMRI signals in amygdala ROI from baseline to post intervention
+3 more
Secondary outcome measures
Change in Anxiety Sensitivity Index (ASI-3) rating during intervention
Change in Anxiety Sensitivity Index (ASI-3) rating from baseline to post intervention
Change in Depression, Anxiety, and Stress Scale (DASS-21) rating during intervention
+12 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Sleep deprivedExperimental Treatment1 Intervention
Overnight sleep deprivation
Group II: RestedActive Control1 Intervention
Well-rested sleep pattern
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sleep deprivation
2016
N/A
~830

Find a Location

Who is running the clinical trial?

1907 FoundationUNKNOWN
Boston University Charles River CampusLead Sponsor
114 Previous Clinical Trials
12,230 Total Patients Enrolled
10 Trials studying Depression
2,353 Patients Enrolled for Depression
One MindUNKNOWN

Media Library

Sleep deprivation Clinical Trial Eligibility Overview. Trial Name: NCT05497414 — N/A
Depression Research Study Groups: Rested, Sleep deprived
Depression Clinical Trial 2023: Sleep deprivation Highlights & Side Effects. Trial Name: NCT05497414 — N/A
Sleep deprivation 2023 Treatment Timeline for Medical Study. Trial Name: NCT05497414 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical research encompass individuals aged 50 and up?

"Participants in this trial must be elder than 18 years old and younger than 80."

Answered by AI

Do I meet the criteria for participation in this research endeavor?

"The investigators of this clinical trial are recruiting sixty individuals who suffer from major depressive disorder (MDD), and range in age between 18 to 80 years old."

Answered by AI

How many volunteers are contributing to this research?

"Yes, the public records on clinicaltrials.gov indicate that this medical research is actively looking for participants. This study was first posted in January 2021 and updated most recently in August 2022; it seeks 60 individuals from one site."

Answered by AI

Are there any openings for volunteers to join this research endeavor?

"Data published on clinicaltrials.gov reveals that this trial is currently seeking participants, having been first posted in late January of 2022 and last updated at the end of August in the same year."

Answered by AI

What key outcomes is this clinical trial attempting to achieve?

"The primary endpoint of this clinical trial, to be measured over a period of one month from beginning to end, is the alteration in fMRI readings taken from the amygdala. Secondary metrics include changes to behavioral response on emotional tasks as judged by milliseconds, alterations in amplitudes for EEG signals (measured in uV^2), and variations recorded through Positive and Negative Affect Scale 21 readings."

Answered by AI

Who else is applying?

What state do they live in?
Massachusetts
Colorado
How old are they?
18 - 65
What site did they apply to?
Boston University
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Neuroimaging Sleep and Mood in Depression
2022. "Neuroimaging Sleep and Mood in Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05497414.
All > Depression Boston
~4 spots leftby Jul 2024
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