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Vitamin C for COVID-19 (LOVIT-COVID Trial)

Phase 3
Waitlist Available
Led By François Lamontagne, MD, FRCPC, MSc
Research Sponsored by Université de Sherbrooke
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

LOVIT-COVID Trial Summary

This trial is testing whether high doses of vitamin C can help improve outcomes for hospitalized COVID-19 patients.

Eligible Conditions
  • COVID-19
  • Vitamin C
  • Coronavirus
  • Hospitalization

LOVIT-COVID Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Death or persistent organ dysfunction
Secondary outcome measures
Acute hemolysis
Global tissue dysoxia
Health related quality of life in 6-month survivors
+12 more

Side effects data

From 2018 Phase 2 trial • 20 Patients • NCT03148236
10%
Pericarditis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vitamin C
Placebo

LOVIT-COVID Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
Vitamin C: 50 mg/kg of weight administered intravenously every 6 hours for 96 hours (16 doses).
Group II: ControlPlacebo Group1 Intervention
Normal saline (0.9% NaCl) or dextrose 5% in water (D5W) in a volume to match the vitamin C.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vitamin C
2017
Completed Phase 4
~18470

Find a Location

Who is running the clinical trial?

Lotte & John Hecht Memorial FoundationOTHER
17 Previous Clinical Trials
4,201 Total Patients Enrolled
1 Trials studying COVID-19
872 Patients Enrolled for COVID-19
Université de SherbrookeLead Sponsor
292 Previous Clinical Trials
69,049 Total Patients Enrolled
4 Trials studying COVID-19
1,606 Patients Enrolled for COVID-19
François Lamontagne, MD, FRCPC, MScPrincipal InvestigatorUniversité de Sherbrooke and CIUSSS de l'Estrie - CHUS

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Lessening Organ Dysfunction With VITamin C - COVID-19
François Lamontagne 2020. "Lessening Organ Dysfunction With VITamin C - COVID-19". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04401150.
~84 spots leftby Apr 2025
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