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Epinephrine for Intraoperative Blood Loss

Phase 3

Waitlist Available

Led By Wonyong Lee, MD

Research Sponsored by The Guthrie Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients who undergo ankle arthroscopic surgery

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up intraoperative

Awards & highlights

Study Summary

"This trial aims to see if adding epinephrine to the irrigation fluid can improve visibility during ankle arthroscopic surgery."

Who is the study for?

This trial is for men and women over 18 who can consent to participate, are undergoing ankle arthroscopic surgery, and do not have cardiac diseases, uncontrolled high blood pressure, or a history of revision surgeries. Pregnant individuals cannot join.Check my eligibility

What is being tested?

The study is testing the effectiveness of adding epinephrine to normal saline irrigation fluid in improving visual clarity during ankle surgery compared to using saline alone.See study design

What are the potential side effects?

Potential side effects may include temporary increased heart rate or blood pressure due to epinephrine absorption. However, these effects are generally mild as the concentration used in irrigation is low.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have had ankle arthroscopic surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ intraoperative

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~intraoperative

This trial's timeline: 3 weeks for screening, Varies for treatment, and intraoperative for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

surgeon's discomfort related to bleeding, measured by visual numeric rating scale

visual clarity during ankle arthroscopic surgery, which will be evaluated by visual analog scale

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: EpinephrineExperimental Treatment2 Interventions

The epinephrine group will have two 3-L normal saline solution bags prepared for each case with 1 mL of 1:1000 epinephrine in each bag (epinephrine concentration 1:3,000,000 for each bag).

Group II: Normal salinePlacebo Group1 Intervention

The control group will have two 3-L normal saline solution bags prepared with no additive

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Epinephrine

2014

Completed Phase 4

~3940

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

The Guthrie ClinicLead Sponsor

25 Previous Clinical Trials

1,790 Total Patients Enrolled

Wonyong Lee, MDPrincipal InvestigatorThe Guthrie Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment for participants currently open in this clinical trial?

"As per clinicaltrials.gov, the current trial is not open for participant enrollment. Initially shared on April 1st, 2024 and updated lastly on February 9th, 2024. Although this specific study has reached its patient quota, it's worth noting that there are currently ongoing recruitment efforts for 22 other trials."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery

2024. "Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06264596.