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Dexamethasone for Knee Stiffness (MUA Trial)

Phase 4
Waitlist Available
Led By Abdel Matthew, M.D.
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks after mua, 1 year after mua
Awards & highlights

MUA Trial Summary

This trial is comparing the outcomes of two groups of people who receive different treatments for stiffness. One group will receive a drug called dexamethasone and another drug called celecoxib. The other group will just receive manipulation.

MUA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks after the mua, and 1 year after the mua
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks after the mua, and 1 year after the mua for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Knee Range of Motion After Manipulation Under Anesthesia
Secondary outcome measures
Knee Injury and Osteoarthritis Outcome Score (KOOS) for Joint Replacement (JR)
Knee Injury and Osteoarthritis Outcome Score (KOOS): Activities of Daily Living (ADL) Score
Knee Injury and Osteoarthritis Outcome Score (KOOS): Pain Score
+14 more

MUA Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MUA with dexamethasone and celecoxibExperimental Treatment2 Interventions
For subjects assigned to the MUA with anti-inflammatory medication group, an intravenous (into the vein) dose of dexamethasone will be given at the time of MUA. Subjects in this group will also receive celecoxib. They will be asked to take the medicine one time daily either at morning or night time with food and water for 2 weeks following MUA. Subjects will also be followed throughout their routine follow up to assess their continued process, and they will fill out questionnaires at the time of their consent and their 6-week and 1-year follow up visits. The questionnaires will take about 15-20 minutes to complete.
Group II: MUA aloneActive Control1 Intervention
Subjects will be given manipulation under anesthesia, will fill out questionnaires about their knee and quality of life and will be followed throughout their routine follow up to assess their continued process. Subjects will fill out questionnaires at the time of their consent and their 6-week and 1-year follow up visits. The questionnaires will take about 15-20 minutes to complete.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexamethasone
2007
Completed Phase 4
~2590
Celecoxib
2019
Completed Phase 4
~1740

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,213 Previous Clinical Trials
3,766,881 Total Patients Enrolled
Knee SocietyUNKNOWN
Abdel Matthew, M.D.Principal InvestigatorMayo Clinic

Media Library

Dexamethasone Clinical Trial Eligibility Overview. Trial Name: NCT02739035 — Phase 4
Knee Stiffness Research Study Groups: MUA with dexamethasone and celecoxib, MUA alone
Knee Stiffness Clinical Trial 2023: Dexamethasone Highlights & Side Effects. Trial Name: NCT02739035 — Phase 4
Dexamethasone 2023 Treatment Timeline for Medical Study. Trial Name: NCT02739035 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met to join this clinical experiment?

"This clinical trial has 130 slots and is only open to those who have had arthroplasty surgery, aged between 18 and 90."

Answered by AI

How widespread is the implementation of this clinical trial?

"Currently, 16 medical centres are participating in this research study. These sites can be found primarily in Cleveland, Charlotte and Philadelphia with other options distributed across the nation. To lessen travel demands if you decide to join the trial, it is recommended that you select a nearby location."

Answered by AI

Could you offer an overview of the other research initiatives involving Celecoxib?

"Celecoxib was first investigated in 2002 by Manitoba Blood & Marrow Transplant Program CancerCare Manitoba. As of now, 1343 trials have been concluded and 590 are actively recruiting around the world - with a significant concentration in Cleveland, Ohio."

Answered by AI

Are there any opportunities for recruitment in this clinical trial at present?

"Current reports on clinicaltrials.gov indicate this trial is not presently enrolling participants; it was first posted April 1st 2016 and most recently updated December 5th 2022. Despite the inactivity, there are 591 other studies actively seeking patients at present."

Answered by AI

How many experimental subjects are taking part in this experiment?

"Presently, this study is not enrolling patients. This research was initially published on April 1st 2016 and underwent its last update 5th December 2022. If you are seeking alternative studies, there are presently one trial of arthroplasty recruiting candidates and a further five hundred ninety experiments involving Celecoxib that have open positions."

Answered by AI

For what indications is Celecoxib typically prescribed?

"Celecoxib is usually prescribed for ophthalmia and sympathetic conditions. In addition, it can be employed to treat communicable diseases, macular edema, and branch retinal vein occlusion."

Answered by AI

Does the research permit seniors above 65 to partake in its experiments?

"In order to participate in this clinical trial, the patient must fall within a certain age range of 18-90 years old. There are 82 separate trials available for patients under 18 and 512 trials open to those over 65."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty
Matthew P. Abdel, M.D. 2016. "MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02739035.
~14 spots leftby Apr 2025
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