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Opioid Analgesic

hydromorphone HCI for Pain relief

N/A
Waitlist Available
Led By Walter Ling, MD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 testing sessions over 12 weeks
Awards & highlights

Study Summary

The aim of this study is to examine the effects of opioid analgesics on acute pain in participants maintained on buprenorphine+naloxone (Suboxone) for opioid use disorders. Seven medication conditions will be tested in a cold pressor test (CPT) paradigm.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 testing sessions over 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 testing sessions over 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain detection
Pain tolerance
Secondary outcome measures
Pupillometry results

Trial Design

7Treatment groups
Experimental Treatment
Placebo Group
Group I: oxycodoneExperimental Treatment1 Intervention
10 mg single dose
Group II: morphine sulfateExperimental Treatment1 Intervention
30mg, single dose,
Group III: hydromorphone HCIExperimental Treatment1 Intervention
4mg single dose
Group IV: hydrocodoneExperimental Treatment1 Intervention
10mg single dose
Group V: buprenorphineExperimental Treatment1 Intervention
4 mg single dose
Group VI: oral tablet placeboPlacebo Group4 Interventions
single dose
Group VII: sublingual tablet placeboPlacebo Group1 Intervention
single dose

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,530 Previous Clinical Trials
10,278,190 Total Patients Enrolled
Indivior Inc.Industry Sponsor
53 Previous Clinical Trials
10,651 Total Patients Enrolled
Walter Ling, MDPrincipal InvestigatorUniversity of California, Los Angeles
1 Previous Clinical Trials
360 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals
Walter Ling 2014. "Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02136784.
All > Opiate Addiction > Probuphine
~1 spots leftby Apr 2025
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