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NMDA Receptor Antagonist

Ketamine-assisted psychotherapy for Depression (KReDO Trial)

Phase 2
Waitlist Available
Led By Eric T Dobson, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16
Awards & highlights

Summary

This trial is testing whether ketamine, given as an injection along with weekly therapy, can help people with a history of opioid addiction who haven't abused opioids in at least 3 months and are currently experiencing depression.

Eligible Conditions
  • Depression
  • Opioid Use Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at baseline, week 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, and 16 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Montgomery Asberg Depression Rating Scale
Secondary outcome measures
Beck Depression Inventory
Brief Pain Inventory (BPI)
Generalized Anxiety Disorder-7 (GAD-7)
+4 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Ketamine-assisted psychotherapyExperimental Treatment1 Intervention
Subjects will receive 8 weekly intramuscular injections of ketamine hydrochloride starting at 0.5 mg/kg and increasing to a maximum dose of 1.5 mg/kg or a total dose of 60 mg, whichever is lower. Ketamine administration will be accompanied by psychotherapy before, after and during the session.

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
947 Previous Clinical Trials
7,398,063 Total Patients Enrolled
41 Trials studying Depression
6,983 Patients Enrolled for Depression
Eric T Dobson, MDPrincipal InvestigatorMedical University of South Carolina
~1 spots leftby Jul 2025