Ketamine for Post-Traumatic Stress Disorder

Queen's University, Kingston, Canada
Post-Traumatic Stress DisorderKetamine - Drug
18 - 65
All Sexes

Study Summary

This trial is testing whether a combination of Ketamine and online Cognitive Behavioural Therapy is effective for treating PTSD.

Eligible Conditions
  • Post Traumatic Stress Disorder

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: 0 weeks from start, 4 weeks from start, 8 weeks from start, and 12 weeks from start

Week 12
Change in Scores on the Clinician Administered PTSD Scale for DSM-5
Change in Scores on the Columbia Suicide Severity Rating Scale
Change in Scores on the Global Assessment of Functioning
Mental Depression
Change in Scores on the Sheehan Disabilities Scale
Week 14
Change in Scores on the Clinical Global Impressions Severity and Improvement Scale
Change in Scores on the Columbia Suicide severity scale

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

3 Treatment Groups

1 of 3
1 of 3
Ketamine + eCBT
1 of 3

Active Control

Experimental Treatment

16 Total Participants · 3 Treatment Groups

Primary Treatment: Ketamine · No Placebo Group · Phase 2

Ketamine + eCBTExperimental Group · 2 Interventions: Online Trauma-Focused Cognitive Behavioural Therapy, Ketamine · Intervention Types: Behavioral, Drug
ControlNoIntervention Group · 1 Intervention: Control · Intervention Types:
Waitlist-ControlNoIntervention Group · 1 Intervention: Waitlist-Control · Intervention Types:
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 0 weeks from start, 4 weeks from start, 8 weeks from start, and 12 weeks from start

Who is running the clinical trial?

Queen's UniversityLead Sponsor
346 Previous Clinical Trials
112,079 Total Patients Enrolled
Taras Reshetukha, MDPrincipal InvestigatorQueen's University

Eligibility Criteria

Age 18 - 65 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You can participate in the trial even if you have thoughts of harming yourself.
You have received at least two different treatments in the past, but neither of them improved your symptoms by more than 50%.
You can participate in the study even if you had a history of substance abuse, except for opioid addiction.

Who else is applying?

What state do they live in?
How old are they?
18 - 65100.0%
What portion of applicants met pre-screening criteria?
Did not meet criteria66.7%
Met criteria33.3%
What site did they apply to?
Queen's University100.0%
Why did patients apply to this trial?
  • "I have severe treatment resistant depression, and nothing has worked in years. Maybe this would work? I'm willing to try a lot of things at this point and I'm based in kingston for the time being so kind of perfect."
How many prior treatments have patients received?

Frequently Asked Questions

Does this medical study permit individuals below the age of 75 to participate?

"This trial requires that participants be between 18 and 65 years of age. In addition, there are 58 clinical trials catering to minors and 410 for seniors." - Anonymous Online Contributor

Unverified Answer

Does my background and health history meet the criteria for participating in this medical experiment?

"The trial is recruiting 16 individuals aged 18 to 65 suffering from stress-related disorders and trauma. To qualify, their symptoms must have been assessed using the CAPS-5 test by a psychiatrist on the team with score of at least 50, they should have received two unsuccessful prior treatments, those with hypertension or cardiovascular disease should be under stable treatment, patients presenting suicidal ideation may join as well as those battling substance abuse (except for opioid use disorder)." - Anonymous Online Contributor

Unverified Answer

How many participants have signed up for this clinical experiment?

"Affirmative. Per the data yielded from, this trial is actively seeking participants and was first posted on August 1st 2021. The current goal is to recruit a total of 16 patients across one site before the study's last update on 8th August 2022." - Anonymous Online Contributor

Unverified Answer

Are there potential health risks with Ketamine usage?

"There is some evidence of Ketamine's safety, so it was adjudged a 2 on the scale. However, no data exists to support its efficacy at this time." - Anonymous Online Contributor

Unverified Answer

Does this medical trial have any vacancies for participants?

" attests that this clinical trial is open for patient recruitment, with the initial post dating back to August 1st 2021 and a recent edit made on the 8th of August 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.