Cyclophosphamide for Carcinoma
This study is evaluating whether genetically engineered T cells may help treat patients with triple negative breast cancer, urothelial cancer, or non-small cell lung cancer.
See full descriptionAbout the trial for Carcinoma
Treatment Groups
This trial involves 2 different treatments. Cyclophosphamide is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Cyclophosphamide will improve 2 primary outcomes and 5 secondary outcomes in patients with Carcinoma. Measurement will happen over the course of 1 year post infusion.
Patient Q & A Section
What are common treatments for carcinoma?
A substantial number of cancers are cured by treatments. For cancer of the breast the most effective treatment is surgery, while for breast cancer that has spread or is otherwise life-threatening, chemotherapy or hormonal therapy may be effective. For cancer of the oesophagus, no standard treatment may be effective.
What causes carcinoma?
There is still little research being done into the cause of carcinoma. Studies are not enough to reveal the reasons for why some lung cancers occur, and how to prevent, detect and cope with carcinoma. However the risk factors of carcinoma are clear, and knowledge of these risk factors can help prevent and treat lung cancers.
What are the signs of carcinoma?
Symptoms are few, except for advanced liver disease. Most patients presenting with symptoms of an inoperable mass, especially for carcinoma, have advanced liver disease. These patients can be found by screening their risk groups during an outreach cancer screening clinic.
How many people get carcinoma a year in the United States?
Around 180,000 people a year in the United States get carcinoma of the colon, and approximately 80,000 people a year get a cancer in the esophagus.
Can carcinoma be cured?
Despite improved staging accuracy, patient survival rates can still only be obtained by following very specific treatment recommendations. The curative potential of radiobiological treatments for carcinoma has to be further examined in future prospective multicenter studies.
What is carcinoma?
Carcinoma can mean cancer from any tissue; this term is not often used by health science professionals because it can provoke confusion and misgendering. Carcinoma is often associated with an underlying benign tumour. We conclude that the term cancer is the best descriptor to identify most of the cancers with metastatic spread.
What are the latest developments in cyclophosphamide for therapeutic use?
Although its role in treatment of neoplastic disease remains a matter of debate, CTX has gained a reputation as an 'antiinflammatory chemotherapy', which produces significant antitumor effect without significant toxicity to patients. More importantly, no increased risk of leukemia or blast crisis was observed when cyclophosphamide alone or with other noncytotoxic drugs was used in neoplastic disease. There was also no significant reduction in the number of neutrapheresis and hospitalization period that occurred when cyclophosphamide was combined with other drugs.
What is cyclophosphamide?
Findings from a recent study has demonstrated that cyclophosphamide therapy for patients in complete clinical response at the time of secondary surgery may be associated with a low rate of relapse and death, but the time to relapse is longer than expected.
Is cyclophosphamide typically used in combination with any other treatments?
There are several other chemotherapy regimens. However, the majority of the patients received less than two cycles of standard Cyclophosphamide for PDA. This may reflect the retrospective nature of the data and the difficulty in standardization of regimens and dosages in the era of modern chemotherapy. Recent findings reinforce the need for randomized and controlled trials of new agents and regimens.
How does cyclophosphamide work?
We conclude that the anti-tumor effects of 2-CPA are most likely due to the generation of an anti-angiogenic environment as a result of an immunosuppressive action. The mechanism of action of 2-CPA in the induction of tumor cell apoptosis is independent of a direct cell cycle inhibition mechanism.
What is the primary cause of carcinoma?
Carcinoma is a complex entity, with its etiology and mechanisms still under active study. It may develop from malignant neoplastic transformation of epithelial cells, or from non-malignant tumors. Carcinoma may be a multi-factorial, multi-stage process involving both genetic abnormalities and environmental factors.
Is cyclophosphamide safe for people?
Based on our small numbers, patients with no risk factors seem to respond most vigorously to cyclophosphamide. However, people older or with risk factors may require a low-dose cyclophosphamide first-line regimen, whereas low-dose or no cyclophosphamide is likely to be appropriate in frail older patients. There is no evidence that the chemotherapy-induced side effects are increased in frail patients. We discuss these findings within the context of current ethical and clinical judgements.