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Vasodilator

INO Treatment for Bronchopulmonary Dysplasia (NOVA2 Trial)

Phase 2 & 3

Waitlist Available

Led By Michael D. Schreiber, M.D.

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up two years

Awards & highlights

NOVA2 Trial Summary

This triallooks at whether nitric oxide can improve brain health in premature babies.

Eligible Conditions

Bronchopulmonary Dysplasia
Premature Infants
Intraventricular Hemorrhage
Periventricular Leukomalacia

NOVA2 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ two years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~two years

This trial's timeline: 3 weeks for screening, Varies for treatment, and two years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Bronchopulmonary dysplasia

Neurodevelopment

Secondary outcome measures

Severe IVH / PVL

NOVA2 Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: INO TreatmentExperimental Treatment1 Intervention

The treatment group will receive iNO, combined with O2 or room air, until 33 weeks corrected age.

Group II: INO ControlPlacebo Group2 Interventions

INO will be given to infants in the control group for the first 7 days of the study gas, then O2 or room air, as clinically appropriate, on the 8th day, until 33 weeks corrected age

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Nitric Oxide

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor

1,003 Previous Clinical Trials

819,265 Total Patients Enrolled

Michael D. Schreiber, M.D.Principal InvestigatorUniversity of Chicago

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some of the common reasons that people take INO Treatment?

"INO Treatment is a common course of action to take when treating hypoxemia. Other conditions that this medical intervention can help with include respiratory failure, anemia, and certain types of cancer."

Answered by AI

How many people can join this medical study?

"Right now, this clinical trial is not looking for new patients to enroll. The study was originally posted on May 1st, 2008 and was last edited on November 7th, 2020. If you are seeking other trials, there are 716 trials for periventricular leukomalacia and 47 trials involving INO Treatment that are currently recruiting."

Answered by AI

Does this research allow for participants that are octogenarians?

"This particular clinical trial is only recruiting patients that are between the ages of 2 hours to 72 hours. Out of the 748 total trials, 312 are for children and 436 are for elderly adults."

Answered by AI

How can I sign up for the clinical trial?

"This trial is for young patients that have periventricular leukomalacia and are between 2 hours and 72 hours old. Up to 484 participants will be enrolled in this clinical study."

Answered by AI

Are patients being sought for this clinical trial at the moment?

"Unfortunately, this particular clinical trial is not currently looking for patients. Although the last update was on November 7th, 2022, it was initially posted over 14 years ago on May 1st, 2008. There are however, 763 other trials that are actively searching for participants."

Answered by AI

What other scientific studies have there been on INO Treatment?

"Currently, there are 47 clinical trials studying the efficacy of INO Treatment. 18 of those active clinical trials are in Phase 3. While the majority of trials for INO Treatment are based in Peradeniya, Ontario, there are 153 locations running studies for this treatment worldwide."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Inhaled Nitric Oxide and Neuroprotection in Premature Infants

2008. "Inhaled Nitric Oxide and Neuroprotection in Premature Infants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00515281.