CLINICAL TRIAL

Manipulation of spatiotemporal coordination during walking for Stroke

Recruiting · 18+ · All Sexes · Los Angeles, CA

This study is evaluating whether a new approach to rehabilitation may help improve walking for individuals who have had a stroke.

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About the trial for Stroke

Treatment Groups

This trial involves 2 different treatments. Manipulation Of Spatiotemporal Coordination During Walking is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Manipulation of spatiotemporal coordination during walking
BEHAVIORAL
Experimental Group 2
Manipulation of spatiotemporal coordination during walking
BEHAVIORAL

Eligibility

This trial is for patients born any sex aged 18 and older. There are 8 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
No musculoskeletal injury or conditions that limit walking ability
No history of neurological disorders or severe head trauma
Absence of cognitive impairment as demonstrated by a Mini-Mental score greater than 24
Inclusion Criteria for Post-Stroke Participants
Presence of unilateral brain lesion from a single stroke
Weakness confined to one side
Ability to walk on a treadmill for five minutes continuously without a cane or walker
Absence of cognitive impairment as demonstrated by a Mini-Mental score greater than 2
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: During study day two
Screening: ~3 weeks
Treatment: Varies
Reporting: During study day two
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: During study day two.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Manipulation of spatiotemporal coordination during walking will improve 4 primary outcomes in patients with Stroke. Measurement will happen over the course of During study day two.

Correlation between angular momentum and step length asymmetry during walking
DURING STUDY DAY TWO
Participants will complete five trials at different levels of step length asymmetry. During these trials, motion capture will be used to measure the kinematics of the body when participants respond to accelerations of the treadmill. This outcome measure will use data from all trials to determine the relationship between angular momentum and step length asymmetry.
DURING STUDY DAY TWO
Oxygen consumption (VO2)
AT THE BEGINNING OF STUDY DAY ONE
The investigators will use a metabolic cart to measure the rate of oxygen consumption (VO2) while participants walk at a fixed speed on a treadmill.
AT THE BEGINNING OF STUDY DAY ONE
Correlation between oxygen consumption (VO2) and step length asymmetry
DURING STUDY DAY ONE
The investigators will use a metabolic cart to measure the rate of oxygen consumption (VO2) while participants walk at a fixed speed on a treadmill. VO2 will be measured in five trials where participants walk with different levels of step length asymmetry. This outcome will capture the relationship between measures of VO2 and step length asymmetry.
DURING STUDY DAY ONE
Angular momentum during walking
AT THE BEGINNING OF STUDY DAY TWO
Motion capture will be used to measure the kinematics of the body when participants respond to accelerations of the treadmill
AT THE BEGINNING OF STUDY DAY TWO

Who is running the study

Principal Investigator
J. F.
Prof. James Finley, Assistant Professor
University of Southern California

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for stroke?

Treatment of a single stroke is uncommon and depends on the treatment of any underlying condition that may have contributed to the accident. Treatment of the patient also depends on the likelihood that the stroke will resolve itself without treatment.

Anonymous Patient Answer

How many people get stroke a year in the United States?

Rates of stroke vary in different cohorts depending on their age and gender. In people < or =65 years the rate is 2.3 per 1000 population while in men it is 3.5 per 1000 population. In women, the rate is 1.7 and 4.5 per 1000 population respectively.

Anonymous Patient Answer

What are the signs of stroke?

Brain lesions that result from a stroke can give rise to many signs and symptoms. The most common symptom is weakness; other symptoms include dizziness, numbness and trouble speaking. More than 50 different signs or symptoms can occur when stroke has occurred. Stroke can cause both temporary and permanent brain damage, and can result from a number of different causes. For more information about stroke risk factors and the signs and symptoms of stroke see the STROKE (STROke IscheMic [IS] stroke and tNSTEMI e[TRIAL] and [INTIMi]stroke Prevention Collaborative (SITS).\n

Anonymous Patient Answer

Can stroke be cured?

The evidence that some treatment interventions work is promising, but there are significant methodological problems related to blinding, randomisation, and attrition. Further research is required to establish effectiveness of some intervention and the optimum type and duration of intervention. The lack of clear differences in outcomes between the group having stroke unit care and the group having usual care care in the current research suggests that it may be inappropriate to equate intensive stroke unit care with 'usual care' stroke units.

Anonymous Patient Answer

What is stroke?

Stroke is a disease with a wide variety of cause, stroke is the 2nd leading cause of death in the United States in 2008. It is a stroke that can't be cured and it is a stroke that we can prevent. Prevention starts with identification and prompt treatment; treatment is the key to achieving the maximum benefit, therefore it is important to identify the risk factors in individuals. In the current era of evidence based care, stroke has the highest mortality of any neurological conditions. There are many treatments including standard and innovative medication, rehabilitation, and some invasive procedures, such as stenting procedures, bypass surgery, and surgical decompression from tumor, ruptured aneurysm, or hematoma.

Anonymous Patient Answer

What causes stroke?

The underlying causes of stroke can be divided into causes related to the blood--brain barrier, blood vessel stiffness and the blood clotting system. These causes may interact and have an effect on the other causes.

Anonymous Patient Answer

Has manipulation of spatiotemporal coordination during walking proven to be more effective than a placebo?

Findings from a recent study demonstrated an increase in the motor planning network for the walking and may facilitate movement recovery from neurorehabilitation. Moreover, it would be recommended that future research be directed toward clinical applications in chronic stroke patients.

Anonymous Patient Answer

Does manipulation of spatiotemporal coordination during walking improve quality of life for those with stroke?

There was no improvement in quality of life in patients who were systematically trained in spatiotemporal coordination during gait. In contrast, these patients who participated in intensive rehabilitation reported improvements in walking speed and a reduced level of dependency on a walker.

Anonymous Patient Answer

How does manipulation of spatiotemporal coordination during walking work?

The manipulation of the spatial structure of walking was not associated with more efficient spatiotemporal coordination during walking for patients with stroke, but it may be useful for patients with mild walking impairments under close supervision in the clinic.

Anonymous Patient Answer

Does stroke run in families?

There seem to be no strong familial clustering of ischemic stroke, but the risk of familial stroke is higher than is the general population. More data, particularly in other forms of stroke are needed to elucidate the underlying mechanism(s) of these associations.

Anonymous Patient Answer

What is the latest research for stroke?

Based on this data, there is growing evidence for the use of thrombolysis, thrombectomy and drug therapy for stroke. A variety of novel neuroprotective agents are being evaluated. Randomized trials are under way to assess different treatment strategies in acute stroke. The new and more efficient statin statin medications must be further investigated for treating atherosclerosis. Statins may be helpful in relieving symptoms of vasospasm after stroke. New and intriguing approaches in the treatment of strokes have been identified. The most promising of these are stroke prevention approaches. These include high-risk screening, early treatment of hypertension with medications such as ACE inhibitors, and treatment of hypertension after stroke with medications like anti-platelet agents.

Anonymous Patient Answer

Is manipulation of spatiotemporal coordination during walking safe for people?

These exploratory preliminary results suggest that individuals with good functional integrity, mobility, and balance could safely engage in a manipulation of spatial navigation skills during walking without fear of impaired walking performance. The manipulation of task-oriented movement of the pelvic girdle from an initial random walk pattern to a more optimal pattern appears to be safe, with or without the use of the LEMS in patients with chronic low back pain.

Anonymous Patient Answer
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