Autologous adipose derived SVF for Vocal Fold Scarring

Phase-Based Progress Estimates
Mayo Clinic in Arizona, Phoenix, AZVocal Fold ScarringAutologous adipose derived SVF - Biological
18 - 65
All Sexes
What conditions do you have?

Study Summary

This trial will study whether fat from a patient's stomach or hips can be used to heal vocal cord scars.

Treatment Effectiveness

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: Baseline, Week 1, and Months 1, 3, 6, 9, 12, and 24

24 months
Adverse events post SVF administration
Month 1
Voice handicap Index

Trial Safety

Trial Design

1 Treatment Group

SVF for treating scarred vocal folds
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Autologous adipose derived SVF · No Placebo Group · Phase 1

SVF for treating scarred vocal folds
Experimental Group · 1 Intervention: Autologous adipose derived SVF · Intervention Types: Biological

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, week 1, and months 1, 3, 6, 9, 12, and 24

Who is running the clinical trial?

Shane A. ShapiroLead Sponsor
1 Previous Clinical Trials
12 Total Patients Enrolled
Amy Rutt, DOPrincipal InvestigatorMayo Clinic

Eligibility Criteria

Age 18 - 65 · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a severe speech problem with a score higher than 60 out of 120 on the voice handicap index.
You have scarring on one or both of your vocal cords.

Who else is applying?

What state do they live in?
How old are they?
18 - 65100.0%
What site did they apply to?
Mayo Clinic in Arizona100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

How responsive is this trial?

Typically responds via

Frequently Asked Questions

Are there any current opportunities to enroll in this experiment?

"As per the information hosted on, no new participants are required for this trial at present. First published on November 1st 2022 and last updated in August of the same year; while there is no recruitment taking place, a separate medical study has opened up signups recently." - Anonymous Online Contributor

Unverified Answer

Who is most suitable for inclusion in this clinical investigation?

"This clinical trial is seeking 12 individuals, aged 18 to 65 with vocal fold scars. Additionally, these patients must have a voice handicap index of at least 60/120 and the scarring must be scored based on laryngoscopic examination (Type I-IV). Informed consent from each participant is needed alongside verification that no woman of childbearing age are pregnant or will become so 4 months prior to and post SVF administration." - Anonymous Online Contributor

Unverified Answer

How does Autologous adipose derived SVF affect patient safety?

"Autologous adipose derived SVF is estimated to have a safety score of 1 due to the limited evidence supporting its efficacy and lack of data regarding its potential risks, as this is currently just in Phase 1." - Anonymous Online Contributor

Unverified Answer

Does this clinical trial have an age restriction, and if so what is the upper limit?

"As outlined in the study's enrollment criteria, only those individuals aged between 18 and 65 are eligible to take part." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.