Your session is about to expire
← Back to Search
Anti-metabolites
PFK-158 for Cancer
Phase 1
Waitlist Available
Research Sponsored by Advanced Cancer Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients must have adequate renal function as evidenced by a serum creatinine ≤ 1.5 X ULN for the reference laboratory OR a calculated creatinine clearance of ≥ 60 mL/min by the Cockroft-Gault equation
Histological or cytological evidence of solid malignancy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of cycle 1 (an average of 1 month)
Awards & highlights
Study Summary
This trial is testing a new cancer drug to see what dose is safe and what side effects it causes. They will also look at whether the drug has any anti-tumor activity.
Who is the study for?
This trial is for adults with advanced solid tumors that haven't responded to standard treatments or who can't tolerate them. They must have a life expectancy over 3 months, be able to perform daily activities with minimal assistance, and have proper organ function. Women of childbearing age need a negative pregnancy test and agree to use contraception.Check my eligibility
What is being tested?
ACT-PFK-158, an experimental drug designed to block cancer cells from using glucose, is being tested for safety and the highest dose patients can take without serious side effects. The study will also look at how the body processes the drug and any signs of it fighting the cancer.See study design
What are the potential side effects?
Potential side effects include reactions related to limiting glucose uptake in cancer cells which may affect energy levels, cause digestive issues or impact blood sugar control. As this is a Phase 1 trial primarily assessing safety, detailed side effect profiles are yet to be determined.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My kidney function is within the normal range.
Select...
My cancer was confirmed by lab tests on tissue or fluid samples.
Select...
I can move around and my doctor thinks I have more than 3 months to live.
Select...
My cancer does not respond to or I cannot tolerate standard treatments.
Select...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ end of cycle 1 (an average of 1 month)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of cycle 1 (an average of 1 month)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Maximum Tolerated Dose
Trial Design
1Treatment groups
Experimental Treatment
Group I: ACT-PFK-158Experimental Treatment1 Intervention
dose escalation
Find a Location
Who is running the clinical trial?
Advanced Cancer TherapeuticsLead Sponsor
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My heart's electrical system functions within a safe range.My kidney function is within the normal range.My liver functions, including AST, ALT, and bilirubin levels, are within the required limits.I have recovered from previous cancer treatments with minimal side effects.I have moderate to severe numbness, pain, or weakness in my hands or feet.I have used blood thinners or clot-dissolving drugs in the last month.My cancer was confirmed by lab tests on tissue or fluid samples.I am a woman who can have children and have a recent negative pregnancy test.I have a brain tumor or cancer that has spread to my brain.I have serious heart-related health issues.I last received monoclonal antibody therapy more than 4 weeks ago or after its half-life period.I agree to use birth control or abstain from sex during the study and for 3 months after.I have not used any experimental drugs or devices within the last 4 weeks or 5 half-lives of the drug.My blood pressure is not controlled even with medication.I only use steroids for replacement, skin, eye issues, or through an inhaler.I can move around and my doctor thinks I have more than 3 months to live.My cancer does not respond to or I cannot tolerate standard treatments.I need to take coumadin.I have diabetes.I am 18 years old or older.I have not had a fever of 38.5°C or higher in the last 3 days.
Research Study Groups:
This trial has the following groups:- Group 1: ACT-PFK-158
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
In how many places is this research endeavor being overseen?
"The James Graham Brown Cancer Center in Louisville, as well as the MD Anderson Cancer Center located in Houston and Lombardi Comprehensive Cancer Centre at Georgetown University are all enrolling patients for this clinical study. Additionally, there exists four additional locations that participants may visit."
Answered by AI
Is this experimentation still open to enrollment?
"The clinicaltrials.gov records reveal that this trial, which was initiated on March 1st 2014 and recently updated June 22nd 2015, is not currently accepting new applicants. Nonetheless, there are an abundance of other medical trials available at the present time - 2800 to be exact."
Answered by AI
Are there any potential dangers associated with PFK-158 treatment?
"Due to the limited data available on PFK-158's safety and efficacy, our team at Power assigned it a score of 1."
Answered by AI
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger