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Alkylating agents
Monoclonal Antibodies + Chemotherapy + Stem Cell Transplant for Non-Hodgkin's Lymphoma
Phase 1
Waitlist Available
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
FVC at least 60% of predicted
Measurable disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is testing a new cancer treatment that uses monoclonal antibodies, drugs that kill cancer cells, and transplants of peripheral stem cells.
Who is the study for?
This trial is for adults with Non-Hodgkin's Lymphoma that hasn't responded to standard treatments. Participants must have a good performance status, adequate bone marrow function, normal liver and kidney tests, no other cancers in the past 5 years, not be pregnant or nursing, and agree to use contraception.Check my eligibility
What is being tested?
The study is testing monoclonal antibody therapy combined with cyclosporine and paclitaxel chemotherapy followed by peripheral stem cell transplantation to see if it can effectively treat patients with refractory Non-Hodgkin's Lymphoma.See study design
What are the potential side effects?
Potential side effects may include reactions at the infusion site, lowered blood counts leading to increased infection risk or bleeding problems, fatigue from anemia or treatment effects on energy levels, liver issues indicated by changes in blood tests of liver function.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My lung function is at least 60% of what is expected.
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My cancer can be measured by medical tests.
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My kidney function is normal or near normal.
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My heart's pumping ability is normal or above.
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I am mostly able to care for myself and carry out daily activities.
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My bone marrow does not show signs of myelodysplastic syndrome.
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My non-Hodgkin's lymphoma did not respond to standard treatments.
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It has been over 4 weeks since my last chemotherapy session.
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I haven't had any cancer except for non-melanoma skin cancer in the last 5 years.
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I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
University of California, DavisLead Sponsor
913 Previous Clinical Trials
4,709,743 Total Patients Enrolled
9 Trials studying Lymphoma
765 Patients Enrolled for Lymphoma
Gerald L. DeNardo, MDStudy ChairUniversity of California, Davis
1 Previous Clinical Trials
1 Trials studying Lymphoma
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My lung function is at least 60% of what is expected.My NHL is aggressive and did not respond to initial treatments aimed at curing it.I have not had any cancer except for non-melanoma skin cancer in the last 5 years.I am HIV positive or have AIDS.My cancer can be measured by medical tests.My kidney function is normal or near normal.My heart's pumping ability is normal or above.I have a history of a bone marrow disorder.I am mostly able to care for myself and carry out daily activities.My bone marrow does not show signs of myelodysplastic syndrome.It has been over 4 weeks since my last external beam radiotherapy.My non-Hodgkin lymphoma did not respond to standard treatments.My non-Hodgkin's lymphoma did not respond to standard treatments.It has been over 4 weeks since my last chemotherapy session.My bone marrow biopsy shows more than 25% non-Hodgkin lymphoma.I haven't had any cancer except for non-melanoma skin cancer in the last 5 years.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any available vacancies for participants in this research project?
"Clinicaltrials.gov data indicates that this medical study, which was published on February 1st 2001 and last updated on August 6th 2013, is not presently recruiting patients. However, there are 1750 other trials actively seeking participants at the moment."
Answered by AI
Has this therapeutic intervention secured the stamp of approval from the FDA?
"As the trial is in Phase 1, with limited safety and efficacy data available, we have assessed the treatment's safety level to be a 1 on our scale."
Answered by AI
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