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N-methyl-D-aspartate (NMDA)-antagonist
Dextromethorphan for Hyperalgesia
Phase 1
Waitlist Available
Led By Margaret A Compton, RN, PhD
Research Sponsored by National Institute on Drug Abuse (NIDA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between the ages of 18 and 55 years of age
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 week
Awards & highlights
Study Summary
This trial will test whether the drug dextromethorphan can help reduce pain in patients with methadone-induced hyperalgesia.
Who is the study for?
This trial is for methadone patients aged 18-55 who have been stable on their dose for at least 6 weeks. They must not be pregnant, nursing, or have conditions like high blood pressure or heart disease that could affect pain response. Participants need to avoid certain medications and agree to use birth control if applicable.Check my eligibility
What is being tested?
The study tests whether dextromethorphan can reduce hyperalgesia in methadone users. It's a double-blind test where neither doctors nor patients know who gets the real medicine versus a placebo. The effect is measured by changes in pain threshold with cold and electrical stimuli.See study design
What are the potential side effects?
Potential side effects of dextromethorphan may include confusion, dizziness, drowsiness, nausea, vomiting, and allergic reactions among others. However, specific side effects related to this trial are not listed.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 55 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 week
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 week
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Pain tolerance
Secondary outcome measures
Pain threshold
Find a Location
Who is running the clinical trial?
National Institute on Drug Abuse (NIDA)Lead Sponsor
2,464 Previous Clinical Trials
2,618,553 Total Patients Enrolled
Margaret A Compton, RN, PhDPrincipal InvestigatorUCLA School of Nursing
1 Previous Clinical Trials
7 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am willing and able to sign a consent form.I have been consistently taking methadone for my condition for at least 6 weeks.You meet the criteria for opiate addiction, as defined by the DSM-IV.I am in good health or have a managed medical or psychiatric condition.I regularly take pain medication for a painful condition.I do not have any severe health conditions like serious heart, liver, or kidney disease.I have a history of high blood pressure, heart disease, stroke, or I currently have a pacemaker.You rely on alcohol, benzodiazepine, or other drugs (except nicotine).I am not severely depressed, acutely psychotic, or at immediate risk of suicide.I am between 18 and 55 years old.I have a condition like neuropathy or schizophrenia that affects how I feel pain.I am not pregnant or nursing and agree to use birth control during the study.I am allergic to dextromethorphan, gabapentin, or oxycodone.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any available openings in this healthcare research endeavor?
"According to information provided on clinicaltrials.gov, this particular trial is not presently seeking participants. The initial posting date was September 1st 2002 and the most recent update occurred January 10th 2017. Although this study isn't taking on new patients right now, there are 9 other trials enrolling at present."
Answered by AI
Does this research accept participants below the age of thirty-five?
"Those who are of legal age and under 55 years old can participate in this trial."
Answered by AI
What are the eligibilty requirements for participating in this trial?
"This medical trial seeks to enrol 40 participants aged 18-55 who suffer from allodynia and meet the following criteria: Be between 18-55 years old, be in good physical health or under a doctor's care for any existing condition, and have no psychiatric disorder that requires continuous treatment."
Answered by AI
What hazards are associated with this therapy for individuals?
"As this is an initial phase 1 trial, the safety of this treatment has been assessed as level 1 due to limited evidence backing up its efficacy."
Answered by AI
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