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MYK-224 for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 52 days
Awards & highlights

Study Summary

This trial will study the effect of combining itraconazole or verapamil with MYK-224, to see if it changes the drug levels of MYK-224 in healthy people.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 52 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 52 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area under the plasma concentration-time curve from time zero extrapolated to infinite time (AUC[INF])
Area under the plasma concentration-time curve from time zero to the time of the last quantifiable concentration (AUC[0-T])
Maximum observed plasma concentration (Cmax)
Secondary outcome measures
Apparent terminal plasma half-life (T-HALF)
Apparent total body clearance (CLT/F)
Measurement of left ventricle stroke volume (LVSV)
+12 more

Trial Design

3Treatment groups
Experimental Treatment
Group I: Arm 3: MYK-224 + VerapamilExperimental Treatment2 Interventions
Group II: Arm 2: MYK-224 + ItraconazoleExperimental Treatment2 Interventions
Group III: Arm 1: MYK-224Experimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MYK-224
2023
Completed Phase 1
~90
Itraconazole
2017
Completed Phase 2
~780
Verapamil
2006
Completed Phase 4
~2290

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,640 Previous Clinical Trials
4,129,419 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants
2022. "A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05304533.
~15 spots leftby Apr 2025
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