← Back to Search

Other

LNZ101 for Eye Diseases

Phase 1
Waitlist Available
Research Sponsored by LENZ Therapeutics, Inc
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 37 days
Awards & highlights

Study Summary

This trial looks at how drugs LNZ101 & LNZ100 are absorbed in the body & how long they stay in the system.

Eligible Conditions
  • Eye Diseases
  • Presbyopia
  • Refractive Errors
  • Brimonidine Tartrate
  • Acetylcholine
  • Eye Drops

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 37 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 37 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
AUC0-inf
AUC0-t
Cmax
+2 more
Other outcome measures
Safety: adverse event reporting

Trial Design

2Treatment groups
Experimental Treatment
Group I: LNZ101Experimental Treatment1 Intervention
Aceclidine 1.75% / Brimonidine combination (non-preserved) ophthalmic solution
Group II: LNZ100Experimental Treatment1 Intervention
Aceclidine 1.75% (non-preserved) ophthalmic solution
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aceclidine + Brimonidine
2022
Completed Phase 3
~500
Aceclidine
2023
Completed Phase 3
~790

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

LENZ Therapeutics, IncLead Sponsor
8 Previous Clinical Trials
1,520 Total Patients Enrolled
5 Trials studying Eye Diseases
1,421 Patients Enrolled for Eye Diseases
ORA, Inc.Industry Sponsor
69 Previous Clinical Trials
9,006 Total Patients Enrolled
14 Trials studying Eye Diseases
2,952 Patients Enrolled for Eye Diseases
Kris GameblinStudy DirectorLENZ Therapeutics

Media Library

Aceclidine (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05936489 — Phase 1
Eye Diseases Research Study Groups: LNZ101, LNZ100
Eye Diseases Clinical Trial 2023: Aceclidine Highlights & Side Effects. Trial Name: NCT05936489 — Phase 1
Aceclidine (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05936489 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age range of this medical trial limited in any way?

"The upper age limit for inclusion in this study is 75 years, while the lower cutoff point sits at 45. For those outside these boundaries, 21 trials are available to participants below 18 and 122 opportunities are open to seniors above 65."

Answered by AI

Is this research effort currently recruiting participants?

"According to clinicaltrials.gov, the recruitment phase for this trial has ended as of June 30th 2023; the initial posting being made on July 6th. Notwithstanding, there are presently 144 other trials actively recruiting patients now."

Answered by AI

Is it possible for me to join this experiment?

"This clinical trial is limited to 30 patients between 45 and 75 years old who are suffering from eye diseases."

Answered by AI

Has the combination of Aceclidine and Brimonidine been sanctioned by the FDA?

"Due to the limited information currently available about Aceclidine + Brimonidine, our team has rated its safety a 1 on a scale of 1-3. This implies that Phase 1 testing is still underway for efficacy and safety assessments."

Answered by AI
~17 spots leftby Apr 2025