This trial is evaluating whether brimonidine tartrate ophthalmic solution 0.025% will improve 2 primary outcomes and 2 secondary outcomes in patients with Glaucoma. Measurement will happen over the course of 60 minutes after application of eye drop.
This trial requires 60 total participants across 2 different treatment groups
This trial involves 2 different treatments. Brimonidine Tartrate Ophthalmic Solution 0.025% is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
Glaucoma may affect more than 20 million Americans, with over 300,000 new cases of glaucoma occurring each year. More than one third of these individuals are unaware they have the disease. Many who are aware that they have glaucoma have not seen a physician for years or years. Many of these patients will benefit from early referral. Results from a recent paper has defined the patient population most likely to benefit from an HVMS.
Many patients with glaucoma are initially satisfied with the results of glaucoma surgery. They perceive improvement of symptomatology, vision, and amblyopia but are unwilling to continue with a careful long-term follow-up regimen. Further investigation is needed to develop a strategy that will maximize the long-term success rate.
Glaucoma patients often present with increased intraocular pressure, but few individuals will require medications to control their intraocular pressure. Frequently, glaucoma is managed with medication but surgical intervention may be appropriate in refractory patients.
The prevalence and knowledge of glaucoma have an impact on the detection and referral pattern of glaucoma. Better knowledge and referral is the key factor for early treatment. The need for eye camps and a well equipped glaucoma department could be beneficial.
The same factors can cause acute angle closure glaucoma and ocular hypertension. Glaucoma develops as a result of the same mechanisms causing the problems of intraocular pressure. The damage to the optic nerve and the consequent loss of visual function is common to all types of glaucoma and all forms of ocular hypertension. It is also important to differentiate the different types of glaucoma as different treatments and patterns of progression may be required. It is the cause of blindness in nearly 10% of Africans.\n
Many patients with glaucoma have no obvious symptoms. Many signs are subjective and vary greatly between patients. Some signs may change over time. An important sign of glaucoma is visual field loss.\n
There is low use of clinical trials in glaucoma. Those who have a high burden of disease for treatment are the most likely to use trials, and those who choose not to use trials as the primary source of information are unlikely to be satisfied or satisfied by the information available.
Brimonidine ophthalmic solution 0.025% had an effect on intraocular pressure (IOP) and did affect iris hue. However, these results did not meet our study's primary objective.
More studies in the next few years are required to answer whether or not bstatolac has a useful role as a steroid-sparing agent in glaucoma. We expect more good evidence to emerge when the current pilot studies are completed.
Average age of diagnosis was not earlier in women than men but age was not significantly different. The age at onset of the pathology in patients who develop glaucoma correlates with age in the general population. There is no evidence of acceleration of onset of glaucoma as age increases
Brimonadin tartrate ophthalmic solution 0.025% treatment results in significant reduction of IOP compared with placebo, at 2, 4, and 8 weeks before intravitreal injection for phakic subjects with medically uncontrolled glaucoma or ocular hypertension. Brimonadin’s favourable safety profile and favourable ocular tolerability profile warrant further consideration in this patient population.
In comparison with the placebo treatment, brimonidine treatment resulted in better improvement in QoL in glaucoma patients in the short term. This suggests that brimonidine tartrate ophthalmic solution 0.025% has a positive effect on glaucoma patients.