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Anti-metabolites

Pemetrexed for Chordoma

Phase 1
Waitlist Available
Led By Santosh Kesari, MD, PhD
Research Sponsored by John Wayne Cancer Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year
Awards & highlights

Study Summary

This trial will test the safety and tolerability of pemetrexed in people with chordoma. Researchers will also collect data on side effects, tumor response, and biomarkers.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression free survival
Radiographic response assessed by RECIST v1.1
Secondary outcome measures
Toxicity assessed by CTCAE v 4.03 criteria

Side effects data

From 2012 Phase 3 trial • 256 Patients • NCT01005680
51%
Neutropenia
47%
Leukopenia
46%
Nausea
43%
Vomiting
35%
Anaemia
31%
Decreased appetite
26%
Haemoglobin decreased
26%
Fatigue
25%
Constipation
25%
White blood cell count decreased
24%
Neutrophil count decreased
19%
Alanine aminotransferase increased
13%
Platelet count decreased
12%
Rash
10%
Aspartate aminotransferase increased
10%
Thrombocytopenia
9%
Blood sodium decreased
8%
Hypokalaemia
7%
Insomnia
7%
Pyrexia
6%
Hyponatraemia
6%
Blood creatinine increased
6%
Lymphopenia
6%
Diarrhoea
6%
Dyspepsia
6%
Red blood cell count decreased
6%
Cough
4%
Dizziness
2%
Bone marrow failure
1%
Ischaemic stroke
1%
Cerebral infarction
1%
Dyspnoea
1%
Pulmonary embolism
1%
Embolism venous
1%
Superior vena cava syndrome
100%
80%
60%
40%
20%
0%
Study treatment Arm
Gemcitabine Plus Cisplatin (GC)
Pemetrexed Plus Cisplatin (PC)

Trial Design

1Treatment groups
Experimental Treatment
Group I: PemetrexedExperimental Treatment1 Intervention
Pemetrexed
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pemetrexed
2014
Completed Phase 3
~5250

Find a Location

Who is running the clinical trial?

John Wayne Cancer InstituteLead Sponsor
21 Previous Clinical Trials
5,534 Total Patients Enrolled
Chordoma FoundationOTHER
2 Previous Clinical Trials
64 Total Patients Enrolled
2 Trials studying Chordoma
64 Patients Enrolled for Chordoma
Eli Lilly and CompanyIndustry Sponsor
2,619 Previous Clinical Trials
3,206,584 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has something like this ever been attempted before?

"Since 2007, Genzyme (a Sanofi Company) has been investigating the efficacy of pemetrexed through clinical trials. After a trial involving 698 patients in 2007, it was approved for Phase 3 drug use and is currently being studied at 225 sites spanning 74 countries and 2395 cities."

Answered by AI

How many individuals have registered for this medical experiment?

"Unfortunately, this trial has reached its recruitment capacity and is not looking for additional participants. It was initially announced on September 6th 2019 and last modified in August 5th 2022. However, 26 trials involving chordoma are enrolling patients while 225 studies related to Pemetrexed have open registration windows."

Answered by AI

For what medical treatments is Pemetrexed commonly prescribed?

"Pemetrexed has been found to be efficacious in treating ovarian cancer as well as unresectable thymomas, mesotheliomas, and non-small cell lung cancers with a localised presentation."

Answered by AI

Has Pemetrexed received endorsement from the FDA?

"The safety of Pemetrexed is estimated to be a 1 according to our team at Power, as this is just an initial trial with limited data regarding its efficacy and security."

Answered by AI

Has Pemetrexed been explored in previous experiments?

"Currently, 225 clinical trials researching Pemetrexed have been launched. Of these, 87 are in the third phase of testing and 19466 locations around the world are conducting studies for this treatment. Winston-Salem in North carolina is hosting most of them."

Answered by AI

Is this experiment currently open to recruitment?

"Unfortunately, this trial is not presently seeking candidates. First published on September 6th 2019 and updated most recently as of August 5th 2022, it is currently inactive. However, there are 26 trials with chordoma research still recruiting participants, in addition to 225 studies utilizing Pemetrexed that have active recruitment processes."

Answered by AI
~3 spots leftby Apr 2025