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Corticosteroid

Group 1: Corticosteroid Injection for Carpal Tunnel Syndrome (IMPACTS Trial)

Phase < 1
Waitlist Available
Research Sponsored by Leslie Witton
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 weeks, 3 months, 6 months, 1 year
Awards & highlights

IMPACTS Trial Summary

This is a multidisciplinary, single-blinded, three-arm randomized controlled trial, comparing perineural hydrodissection and steroid injection for the treatment of CTS. Patients are screened based on pre-established eligibility criteria and randomized to one of the three study groups. Patients are followed at 6-week, 3-month, 6-month, and 12-month time points to assess the primary and secondary outcomes of the study, which include both patient-reported outcome measures and objective clinical assessments.

Eligible Conditions
  • Carpal Tunnel Syndrome

IMPACTS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 weeks, 3 months, 6 months, 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 weeks, 3 months, 6 months, 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Boston Carpal Tunnel Questionnaire (BCTQ)
Secondary outcome measures
Change in Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire
Change in Electromyographic Measurement- Amplitude
Change in Electromyographic Measurement- Motor Conduction Velocity
+3 more

IMPACTS Trial Design

2Treatment groups
Experimental Treatment
Group I: Group 2: Perineural HydrodissectionExperimental Treatment1 Intervention
Patients in this group will undergo a perineural hydrodissection plus an injection of corticosteroid into the carpal tunnel, as a novel technique.
Group II: Group 1: Corticosteroid InjectionExperimental Treatment1 Intervention
Patients in this group will undergo an injection of corticosteroid into the carpal tunnel as per current treatment practices.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Corticosteroid Injection
2018
Completed Phase 4
~360

Find a Location

Who is running the clinical trial?

Leslie WittonLead Sponsor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
IMpact of Perineural Hydrodissection Over Alternative Therapies in Patients With Carpal Tunnel Syndrome
Leslie Witton 2018. "IMpact of Perineural Hydrodissection Over Alternative Therapies in Patients With Carpal Tunnel Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03616353.
All > Carpal Tunnel
~9 spots leftby May 2025
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