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Behavioral Intervention

Exposure Therapy for PTSD

N/A

Waitlist Available

Led By Deborah Beidel, Ph.D.

Research Sponsored by University of Central Florida

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Active duty military personnel with a diagnoses of PTSD

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months posttreatment

Awards & highlights

Study Summary

This trial is testing different exposure therapies to find the most effective one for treating PTSD in active duty service members and veterans. The goal is to improve their mental health and reduce the economic burden of PTSD.

Who is the study for?

This trial is for active duty military personnel and veterans who have PTSD from a traumatic event during service, including those with military sexual trauma. It's not for individuals using benzodiazepines, or those with schizophrenia, antisocial personality disorder, acute heart issues, severe substance abuse problems, or moderate to severe TBI.Check my eligibility

What is being tested?

The study is testing the effectiveness of two types of exposure psychotherapy—Trauma Management Therapy and Prolonged Exposure Therapy—to treat PTSD in service members and veterans. The goal is to find which therapy better improves mental health.See study design

What are the potential side effects?

Exposure therapies may cause temporary increases in distress due to recalling traumatic events. Participants might experience heightened anxiety or emotional discomfort during sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am in the military and have been diagnosed with PTSD.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months posttreatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months posttreatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months posttreatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from Baseline on the Clinician-Administered PTSD Scale for DSM-5

Secondary outcome measures

Change from Baseline on the Moral Injury Event Scale (MIES)

Change from Baseline on the Posttraumatic Cognitions Inventory (PTCI)

Change from Baseline on the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)

+13 more

Trial Design

3Treatment groups

Active Control

Group I: Trauma Management TherapyActive Control1 Intervention

1. Trauma Management Therapy (TMT; Turner, Beidel, & Frueh, 2005): TMT is a multicomponent behavioral treatment program designed to target various aspects of chronic PTSD - reducing emotional and physiological reactivity to traumatic cues, reducing intrusive symptoms and avoidance behavior, improving interpersonal skills and emotion modulation (e.g., anger control), and increasing the range of enjoyable social activities. In this investigation and in line with our previous publications, TMT will include virtual-reality augmented exposure (i.e. olfactory stimulation, heart rate, and skin conductance); group therapy to address sleep, anger, depression, and social isolation; homework assignments; and programmed practice. In the 3-week treatment program, each participant receives virtual-reality assisted exposure in the morning followed by in vivo exposure and group therapy (SER) each afternoon for a total of 29 sessions.

Group II: Prolonged ExposureActive Control1 Intervention

2. Standard Prolonged Exposure (PE; Foa, Hembree, & Rothbaum, 2007) consists of psychoeducation, imaginal exposure to trauma memories, in vivo exposure to situations that are avoided due to their association with the trauma, and emotional processing. The standard protocol consists of 12 imaginal exposure sessions, along with in vivo exposure/homework assignments and listening to a recording of the imaginal sessions at home during the evening.

Group III: Compressed Prolonged ExposureActive Control1 Intervention

3. Compressed PE consists of 10 standard PE sessions delivered on consecutive work days. The imaginal exposure sessions take place in the morning, with in vivo exposures assigned (not therapist accompanied) for the afternoons. Patients are instructed to listen to the recordings of the imaginal exposure each night. Being most concerned with having enough time for in vivo practice, Session 1 does not start on a Monday, allowing for two full weekends in order to maximize in vivo exposures. Both versions of PE average 36 total treatment hours.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Central FloridaLead Sponsor

78 Previous Clinical Trials

1,097,176 Total Patients Enrolled

Deborah Beidel, Ph.D.Principal InvestigatorUniversity of Central Florida

Media Library

Prolonged Exposure Therapy (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04549493 — N/A

Post-Traumatic Stress Disorder Research Study Groups: Trauma Management Therapy, Prolonged Exposure, Compressed Prolonged Exposure

Post-Traumatic Stress Disorder Clinical Trial 2023: Prolonged Exposure Therapy Highlights & Side Effects. Trial Name: NCT04549493 — N/A

Prolonged Exposure Therapy (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04549493 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals 40 years of age or older being solicited to participate in this experiment?

"Eligible individuals for this medical trial must be between the ages of 18 and 64. It is worth noting there are 152 trials seeking participants under 18 years old and 823 studies recruiting patients above 65."

Answered by AI

Would I be eligible to partake in this experiment?

"Three hundred individuals between 18 and 64 years of age with a wound are eligible to join this study. Furthermore, applicants need to satisfy the following requirements: be in active military service; have PTSD stemming from events that occurred during their tenure; or have endured attempted or completed sexual assault as part of their service."

Answered by AI

Are there still vacancies available in this medical experiment?

"Clinicialtrials.gov states that the trial, which was initially announced on February 12th 2020 and last updated November 1st 2022, is not currently looking for patients. However, there are a total of 1043 other studies actively seeking participants right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy

2020. "Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04549493.