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Behavioral Intervention

Prolonged Exposure for Post-Traumatic Stress Disorder (PEP Trial)

N/A

Waitlist Available

Led By Wendy Muzzy, MRA, MLIS

Research Sponsored by Medical University of South Carolina

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 36 weeks

Awards & highlights

PEP Trial Summary

This trial will test whether or not having a peer support 'workout buddy' for in vivo exposure therapy helps veterans with PTSD who have prematurely dropped out of treatment to return and complete their therapy.

Eligible Conditions

Post-Traumatic Stress Disorder
Anxiety Disorders
Psychiatric Disorder

PEP Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Post-Traumatic Stress Disorder

Secondary outcome measures

Barriers to Therapeutic Exposure Scale (BTES)

Combat Exposure Scale (CES)

Deployment Risk and Resilience Inventory-2 (DRRI-2)

+7 more

Side effects data

From 2015 Phase 2 trial • 142 Patients • NCT00937235

89%

Miscellaneous

Suicidal Ideation

Respiratory issue

Broken ankle + hospitalization

Hospitalization secondary to drug or alcohol relapse

100%

80%

60%

40%

20%

Study treatment Arm

Integrated Treatment

Varenicline

PEP Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: PE+Exposure Workout BuddyExperimental Treatment1 Intervention

Prolonged Exposure with assistance of Veteran who has successfully completed treatment to meet patients at exposure sites in the community to offer support during exposure.

Group II: PE+Peer General SupportActive Control1 Intervention

Prolonged Exposure with assistance of Veteran who has successfully completed treatment to call and talk to patients once per week, informally meet at patient appointments, encourage session attendance and check in about progress.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Prolonged Exposure

2010

Completed Phase 3

~1440

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Charleston Research InstituteOTHER

3 Previous Clinical Trials

473 Total Patients Enrolled

Medical University of South CarolinaLead Sponsor

932 Previous Clinical Trials

7,394,120 Total Patients Enrolled

Wendy Muzzy, MRA, MLISPrincipal InvestigatorMedical University of South Carolina

1 Previous Clinical Trials

27 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities for volunteers to join this research project?

"The clinical trial that was originally posted on May 1, 2018 and edited last month is no longer recruiting participants. Nevertheless, there are currently 1732 other active trials in need of patients."

Answered by AI

Recent research and studies

TrialsJournal

Peer Support During in Vivo Exposure Homework to Reverse Attrition from Prolonged Exposure Therapy for Posttraumatic Stress Disorder (PTSD): Description of a Randomized Controlled Trial

Hernandez-Tejada, Melba A., Wendy Muzzy, Matthew Price, Stephanie Hamski, Stephanie Hart, Edna Foa, and Ron Acierno. 2020. “Peer Support During in Vivo Exposure Homework to Reverse Attrition from Prolonged Exposure Therapy for Posttraumatic Stress Disorder (PTSD): Description of a Randomized Controlled Trial”. Trials. Springer Science and Business Media LLC. doi:10.1186/s13063-020-04302-5.

clinicaltrials.govStudy

Peer Social Support During In Vivo Exposure for PTSD

Wendy Muzzy 2018. "Peer Social Support During In Vivo Exposure for PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03485391.