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Noninvasive Brain Stimulation

Transcranial Magnetic Stimulation for Cognitive Function

N/A
Recruiting
Led By Derek E Nee, PhD
Research Sponsored by Florida State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, pre-intervention and immediately after intervention
Awards & highlights

Study Summary

This trial looks at how a non-invasive brain stimulation called TMS affects brain regions linked to focus and attention.

Who is the study for?
This trial is for right-handed individuals aged 18-30 who speak English fluently, having learned it by age 6. It's not suitable for those with neurological or psychiatric disorders, pregnant women, people with tinnitus, a family history of epilepsy, or anyone taking pro-epileptic drugs or medications.Check my eligibility
What is being tested?
The study is testing the effects of transcranial magnetic stimulation (TMS) on two brain areas: the prefrontal cortex and posterior parietal cortex. TMS is a non-invasive procedure that uses magnetic fields to stimulate nerve cells in the brain.See study design
What are the potential side effects?
Potential side effects of TMS may include discomfort at the site of stimulation, headache, lightheadedness, tingling sensations on the scalp or face during treatment. Serious side effects are rare but can include seizures.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, pre-intervention and immediately after intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, pre-intervention and immediately after intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in PFC-PPC activation
Change in PFC-PPC effective connectivity
Secondary outcome measures
Change in contextual control accuracy
Change in contextual control speed
Change in temporal control accuracy
+1 more

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: MFG-TMSExperimental Treatment1 Intervention
Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
Group II: FPl-TMSExperimental Treatment1 Intervention
Transcranial magnetic stimulation to the lateral frontal pole. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
Group III: S1-TMSActive Control1 Intervention
Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
transcranial magnetic stimulation
2013
Completed Phase 2
~710

Find a Location

Who is running the clinical trial?

Florida State UniversityLead Sponsor
200 Previous Clinical Trials
31,718 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,669 Total Patients Enrolled
Derek E Nee, PhDPrincipal InvestigatorFlorida State University
1 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

TMS (Noninvasive Brain Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT05878080 — N/A
Transcranial Magnetic Stimulation Research Study Groups: FPl-TMS, MFG-TMS, S1-TMS
Transcranial Magnetic Stimulation Clinical Trial 2023: TMS Highlights & Side Effects. Trial Name: NCT05878080 — N/A
TMS (Noninvasive Brain Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05878080 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial provide an option for minors?

"This investigation is open to individuals between the age of 18 and 30."

Answered by AI

Are there current opportunities to participate in this clinical experiment?

"Affirmative. Information available on clinicaltrials.gov hints that this medical trial, which was first published on May 15th 2023 is presently looking for participants to join the study. In total, 40 patients are required from two different sites."

Answered by AI

What goals is this investigation hoping to accomplish?

"This clinical trial, observed from baseline to post-intervention, aims at investigating modifications in the effective connectivity between prefrontal cortex and posterior parietal cortex (PFC-PPC). Additionally, temporal control accuracy (percent correct on conditions with temporal control during a comprehensive task), contextual control speed (RTs measured in milliseconds for conditions requiring context management) and contextual control accuracy (also RTs measured in ms for the same purpose) are being assessed as secondary objectives."

Answered by AI

Who is qualified to participate in this medical experiment?

"This clinical trial is seeking to recruit 40 participants and requires that any applicant has experience with transcranial magnetic stimulation, as well as be in the age range of 18-30."

Answered by AI

What is the current scale of enrollment for this medical trial?

"Affirmative, the details on clinicaltrials.gov indicate that this medical trial is currently recruiting patients to participate. The research was initially put up on May 15th 2023 and recently updated as of May 25th 2023. 40 participants are desired from two separate sites."

Answered by AI

Who else is applying?

What site did they apply to?
Florida State University Psychology Department Building
FSU MRI Facility
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

Interested in brain behavior from my work at Google and Microsoft.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Florida State University Psychology Department Building: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
iTBS/fMRI Study of Hierarchical Control in the PFC
Derek Nee 2023. "iTBS/fMRI Study of Hierarchical Control in the PFC". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05878080.
All > Transcranial Magnetic Stimulation
~14 spots leftby Nov 2024
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