940 Participants Needed

Physician Notification for Aortic Stenosis

(DETECT AS Trial)

RA
PJ
Overseen ByParis Jamiel
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Massachusetts General Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests if sending doctors alerts about patients with severe heart valve problems can improve treatment and reduce care differences among different groups.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is the Physician Notification for Aortic Stenosis generally safe for humans?

The research articles do not provide specific safety data for the Physician Notification for Aortic Stenosis or similar systems. They focus on improving adverse event reporting and alert systems, but do not address the safety of these notification systems themselves.12345

How does the Physician Notification for Aortic Stenosis treatment differ from other treatments for this condition?

The Physician Notification for Aortic Stenosis treatment is unique because it involves using electronic health record (EHR) alerts to notify physicians about patient conditions, which can improve timely follow-up and management compared to traditional methods that may not provide real-time updates.36789

What data supports the effectiveness of this treatment for aortic stenosis?

Research shows that electronic alerts and notifications can improve communication and coordination among healthcare providers. For example, automated systems have been effective in ensuring timely follow-up care and improving awareness of patient conditions, which suggests that similar notification systems could help manage aortic stenosis by keeping physicians informed and facilitating better care coordination.37101112

Are You a Good Fit for This Trial?

This trial is for patients with severe aortic stenosis, where the opening of their aortic valve is less than or equal to 1.0cm2. It's not for those who already have artificial (bioprosthetic or mechanical) valves in place.

Inclusion Criteria

My heart valve is severely narrowed.

Exclusion Criteria

You have a replacement valve in your aorta.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Providers in the intervention group receive electronic notifications about patients with severe aortic stenosis, highlighting management guidelines.

1 year

Follow-up

Participants are monitored for AVR utilization, mortality, heart failure hospitalization, and other secondary outcomes.

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Physician Notification Letter
Trial Overview The DETECT AS Trial tests if notifying physicians electronically about their patient's severe aortic stenosis improves management and increases the use of valve replacement surgery, especially among different ethnic and racial groups.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Notification Letter ArmExperimental Treatment1 Intervention
Group II: Control GroupActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Massachusetts General Hospital

Lead Sponsor

Trials
3,066
Recruited
13,430,000+

Edwards Lifesciences

Industry Sponsor

Trials
188
Recruited
67,500+
Founded
1958
Headquarters
Irvine, California, U.S.
Known For
Structural Heart Innovations
Top Products
SAPIEN Transcatheter Heart Valve, EVOQUE System, PASCAL Precision, SAPIEN M3
Todd Brinton profile image

Todd Brinton

Edwards Lifesciences

Chief Medical Officer since 2023

MD from Stanford University

Bernard Zovighian profile image

Bernard Zovighian

Edwards Lifesciences

Chief Executive Officer since 2023

MBA from INSEAD

Published Research Related to This Trial

The study involving 28 ED triage nurses and over 39,000 patients found that a passive EHR alert did not significantly increase the utilization of triage protocols for diagnostic testing in emergency settings.
Despite some increases in protocol implementation after the intervention, the overall benefits of using EHR alerts were minimal, suggesting that more rigorous studies are needed to optimize alert systems for improving patient care.
Electronic alerts for triage protocol compliance among emergency department triage nurses: a randomized controlled trial.Holmes, JF., Freilich, J., Taylor, SL., et al.[2018]
The implementation of a computerized alert system in primary care significantly improved the initiation of osteoporosis treatment among high-risk patients, with 30% starting treatment within 2 years of the alert activation.
The time to treatment initiation decreased notably after the alert system was introduced, with initiation rates within 6 months rising from 52% to 59.8% for T-score cases, indicating the system's effectiveness in addressing previously missed cases.
Development and efficacy of a computerized decision support system for osteoporosis management in the community.Goldshtein, I., Shamai-Lubovitz, O., Guindy, M., et al.[2020]
An automated email notification system was implemented to inform physicians about finalized test results pending at discharge (TPADs), improving communication and responsibility transfer between inpatient and primary care physicians.
During a 6-month pilot involving randomly selected inpatient-attending physicians, 84% reported satisfaction with the system, indicating its effectiveness in managing TPADs with an average of 1.6 notifications per discharged patient.
Design and implementation of an automated email notification system for results of tests pending at discharge.Dalal, AK., Schnipper, JL., Poon, EG., et al.[2021]

Citations

Electronic alerts for triage protocol compliance among emergency department triage nurses: a randomized controlled trial. [2018]
Development and efficacy of a computerized decision support system for osteoporosis management in the community. [2020]
Design and implementation of an automated email notification system for results of tests pending at discharge. [2021]
Where are my patients? It is time to automate notification of hospital use to primary care practices. [2011]
Detecting alerts, notifying the physician, and offering action items: a comprehensive alerting system. [2018]
If you don't know where you are going, you can't tell if you have arrived: defining goals for drug safety announcements. [2018]
Using electronic medical records to enhance detection and reporting of vaccine adverse events. [2018]
Integrating Adverse Event Reporting Into a Free-Text Mobile Application Used in Daily Workflow Increases Adverse Event Reporting by Physicians. [2021]
Primary Care Providers' Opening of Time-Sensitive Alerts Sent to Commercial Electronic Health Record InBaskets. [2019]
10.United Statespubmed.ncbi.nlm.nih.gov
Notifications received by primary care practitioners in electronic health records: a taxonomy and time analysis. [2022]
Impact of event notification services on timely follow-up and rehospitalization among primary care patients at two Veterans Affairs Medical Centers. [2022]
12.United Statespubmed.ncbi.nlm.nih.gov
Characterization of public health alerts and their suitability for alerting in electronic health record systems. [2019]
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