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rTMS + CBIT for Tic Disorders (TICS-CIHR Trial)

N/A
Waitlist Available
Led By Frank P MacMaster, PhD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 11
Awards & highlights

TICS-CIHR Trial Summary

This trial is investigating whether pairing 3 weeks of repetitive transcranial magnetic stimulation (rTMS) and hormone replacement therapy (HRT) can reduce tic severity in children and adolescents with Tourette's Syndrome (TS).

Eligible Conditions
  • Tic Disorders

TICS-CIHR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 11
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 11 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Yale Global Tic Severity Scale Total Tic score (YGTSS)
Secondary outcome measures
Functional connectivity of the Supplementary Motor Area (SMA) and the dominant Primary Motor Cortex (M1)
Supplementary Motor Area (SMA) GABA concentration as measured by LCModel (Institutional Units)
Other outcome measures
Yale Global Tic Severity Scale Total Tic score (YGTSS) post CBIT

TICS-CIHR Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: rTMS + CBITExperimental Treatment2 Interventions
Repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)
Group II: Sham rTMS + CBITActive Control1 Intervention
Sham repetitive transcranial magnetic stimulation (rTMS) and Comprehensive Behavioural Intervention for Tics (CBIT)

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
792 Previous Clinical Trials
869,104 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,344 Previous Clinical Trials
26,453,367 Total Patients Enrolled
2 Trials studying Tic Disorders
274 Patients Enrolled for Tic Disorders
Frank P MacMaster, PhDPrincipal InvestigatorUniversity of Calgary
2 Previous Clinical Trials
63 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
BMJ OpenJournal
Targeted Interventions in Tourette’s Using Advanced Neuroimaging and Stimulation (TITANS): Study Protocol for a Double-blind, Randomised Controlled Trial of Transcranial Magnetic Stimulation (TMS) to the Supplementary Motor Area in Children with Tourette’s Syndrome
Kahl, Cynthia K, Rose Swansburg, Adam Kirton, Tamara Pringsheim, Gabrielle Wilcox, Ephrem Zewdie, Ashley Harris, et al.. 2021. “Targeted Interventions in Tourette’s Using Advanced Neuroimaging and Stimulation (TITANS): Study Protocol for a Double-blind, Randomised Controlled Trial of Transcranial Magnetic Stimulation (TMS) to the Supplementary Motor Area in Children with Tourette’s Syndrome”. BMJ Open. BMJ. doi:10.1136/bmjopen-2021-053156.
clinicaltrials.govStudy
TICS: Transcranial Magnetic Stimulation for Intervening in Children With Tourette's Syndrome (CIHR)
Frank MacMaster, PhD 2019. "TICS: Transcranial Magnetic Stimulation for Intervening in Children With Tourette's Syndrome (CIHR)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03844919.
All > Transcranial Magnetic Stimulation
~9 spots leftby Apr 2025
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