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Bone Graft

Bone Graft Comparison for Tooth Loss (PilotXenAllo Trial)

N/A

Waitlist Available

Led By Sejal Thacker, D.D.S.

Research Sponsored by UConn Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Single rooted non molar teeth needing extraction for miscellaneous reasons (since histological analysis is being done, it is essential to harvest bone core biopsies without inclusion of native bone)

Good general oral health (no active periodontal disease, absence of hopeless teeth, absence of active caries, absence of acute infections)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

PilotXenAllo Trial Summary

This trial compares the changes in extraction sockets of single rooted teeth, six months after extraction, when grafted with either xenograft or allograft.

Who is the study for?

This trial is for adults over 21 with good oral health, requiring single-rooted tooth extraction but no active infections or severe dental issues. It excludes those with systemic conditions, chronic antibiotic/steroid use, pregnancy, heavy smoking (>10 cigarettes/day), and certain medical histories like bone disorders or HIV.Check my eligibility

What is being tested?

The study compares the changes in the tooth socket's dimensions after an extraction when filled with either a xenograft (tissue from another species) or an allograft (human donor tissue). The comparison occurs over a six-month period post-extraction.See study design

What are the potential side effects?

While specific side effects are not listed for this type of procedure, common risks may include infection at the graft site, inflammation, discomfort or pain at the extraction site, and potential rejection of graft material.

PilotXenAllo Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I need a non-molar tooth removed for reasons other than decay or injury.

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My oral health is good, with no gum disease, tooth decay, or infections.

Select...

I have natural teeth next to the one that needs to be pulled out.

Select...

I don't have signs of infection like pus or abscesses in the tooth to be extracted.

Select...

I am 21 years old or older.

PilotXenAllo Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Horizontal and vertical dimensional changes noted on Cone Beam Computed Tomography

Secondary outcome measures

Histologic analysis of bone biopsy cores

Horizontal dimensional changes measured intra-operatively using a Periodontal Probe

Vertical dimensional changes measured intra-operatively using a periodontal probe and stent

PilotXenAllo Trial Design

2Treatment groups

Active Control

Group I: XenograftActive Control1 Intervention

Group II: AllograftActive Control1 Intervention

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

UConn HealthLead Sponsor

211 Previous Clinical Trials

60,609 Total Patients Enrolled

Institut Straumann AGIndustry Sponsor

52 Previous Clinical Trials

2,627 Total Patients Enrolled

8 Trials studying Tooth Loss

472 Patients Enrolled for Tooth Loss

Sejal Thacker, D.D.S.3.04 ReviewsPrincipal Investigator - UConn Health

UConn Health

Media Library

Bone graft (Bone Graft) Clinical Trial Eligibility Overview. Trial Name: NCT04550689 — N/A

Tooth Loss Research Study Groups: Xenograft, Allograft

Tooth Loss Clinical Trial 2023: Bone graft Highlights & Side Effects. Trial Name: NCT04550689 — N/A

Bone graft (Bone Graft) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04550689 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals able to join this research endeavor at present?

"While the timeline on clinicaltrials.gov marks this trial as no longer recruiting, it was first posted in October 2020 and last updated at March 2022. Fortunately, 33 other trials are presently seeking participants."

Answered by AI

Who else is applying?

What state do they live in?

New York

What site did they apply to?

UConn Health

What portion of applicants met pre-screening criteria?

Met criteria

Did not meet criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

I've lossed several teeth, and sure I'm going to loose more, if I can help new technology and get help at same time it's a win, win.

PatientReceived 1 prior treatment

I haven't had medical insurance in a Long time or dental i had a head on collision that messed up my dental Health and i have had six kids so i haven't had no way to take care of my own conditions plus i suffer from bipolar and post traumatic stress disorder and depression that it just kept driving me deeper into my depression.

PatientReceived no prior treatments

Recent research and studies

clinicaltrials.govStudy

Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft

Sejal Thacker 2020. "Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04550689.

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