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Root Canal Filler
Gutta Percha for Tooth Pulp Necrosis (NDGX Trial)
Phase 2 & 3
Waitlist Available
Led By Dean Ho, Ph.D.
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
NDGX Trial Summary
This trial is comparing the success of two root canal filler materials: gutta percha and nanodiamond-modified gutta percha.
Eligible Conditions
- Tooth Pulp Necrosis
- Dental Pulp Disease
- Nerve Root Pain
NDGX Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Root canal treatment success
NDGX Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: ND and Amox modified Gutta PerchaExperimental Treatment2 Interventions
Subjects in both arms of the study will be receiving standard of care RCT and routine follow-up examinations/assessments at 6 months, 1 year, and 2 years post RCT. The difference between the two arms will be the root canal filler material used. The root canals for the treatment arm of the study will be filled with gutta percha at the apical third, gutta percha modified with nanodiamonds and amoxicillin (NDGX) will be used for the middle and coronal thirds.
Group II: Gutta PerchaActive Control1 Intervention
Subjects in both arms of the study will be receiving standard of care RCT and routine follow-up examinations/assessments at 6 months, 1 year, and 2 years post RCT. For all the patients into the control arm of the study, the root canals will be filled with gutta percha (current standard of care), using the vertical condensation obturation technique (standard of care RCT technique).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Gutta Percha
2016
N/A
~10
Find a Location
Who is running the clinical trial?
University of California, Los AngelesLead Sponsor
1,528 Previous Clinical Trials
10,276,851 Total Patients Enrolled
Dean Ho, Ph.D.3.02 ReviewsPrincipal Investigator - University of California, Los Angeles
University of California, Los Angeles
Mo K Kang, Ph.D,D.D.S.Principal InvestigatorUniversity of California, Los Angeles
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You are taking medication for osteoporosis or receiving intravenous bisphosphonates.You have molars (back teeth).You have allergies to dental materials.You are allergic to penicillin or amoxicillin.
Research Study Groups:
This trial has the following groups:- Group 1: ND and Amox modified Gutta Percha
- Group 2: Gutta Percha
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
For what medical condition is Gutta Percha most commonly prescribed?
"helicobacter pylori infection is most commonly treated with Gutta Percha. This therapy can also be used to help patients suffering from other conditions like bacterial infections, community acquired pneumonia (cap), and acute otitis media (aom)."
Answered by AI
How many people are allowed to be in this clinical trial?
"That is correct. The listing on clinicaltrials.gov affirms that the study is open for recruitment and 54 patients are needed at a single site. This trial was first made public on June 1, 2023 and underwent its most recent revision on May 16, 2022."
Answered by AI
Are new participants being sought for this clinical trial?
"The most recent update to this clinical trial's information on clinicaltrials.gov was on May 16th, 2022. This means that the study is still recruiting patients, as it has been since it was originally posted on June 1st, 2023."
Answered by AI
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