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Stem Cell Therapy

Bone marrow concentrate for Rotator Cuff Tears

N/A

Waitlist Available

Led By Matthew J Best, MD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 years.

Awards & highlights

Study Summary

This trial is comparing the benefits of using different amounts of bone marrow from the upper arm in repairing a shoulder tendon.

Who is the study for?

This trial is for individuals with rotator cuff tears. Specific eligibility details are not provided, but typically participants would need to be in good health otherwise and able to undergo the procedures involved in the trial.Check my eligibility

What is being tested?

The study is testing two methods of repairing rotator cuffs: one using whole bone marrow and another using concentrated bone marrow from the upper arm bone. It's a randomized controlled trial, meaning patients are randomly assigned to either method to compare outcomes.See study design

What are the potential side effects?

While specific side effects aren't listed, common risks may include pain at the injection site, infection, bleeding or bruising. There could also be complications related to anesthesia or reactions specific to stem cell treatments.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years.

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of Rotator cuff re-tears as assessed by magnetic resonance imaging

Secondary outcome measures

American Shoulder and Elbow Surgeons Score

Comprehensive Shoulder Assessment

Rate of oral and/or intra-articular corticosteroid required

+3 more

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Bone marrow concentrateExperimental Treatment1 Intervention

20cc of whole bone marrow concentrated (varying quantities)

Group II: 20cc bone marrow aspirateExperimental Treatment1 Intervention

Bone marrow aspirate, 20cc

Group III: 4cc bone marrow aspirateActive Control1 Intervention

Bone marrow aspirate, 4cc

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,267 Previous Clinical Trials

14,837,412 Total Patients Enrolled

1 Trials studying Rotator Cuff Tears

ON FoundationUNKNOWN

Matthew J Best, MDPrincipal InvestigatorJohns Hopkins University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it feasible for me to be a participant in this clinical investigation?

"Patients aged between 20 and 75 with diagnosed rotator cuff tears are sought for participation in this research project, aiming to enroll approximately 150 individuals."

Answered by AI

Are there any available vacancies for patient participation in this clinical trial?

"Information on clinicaltrials.gov states that this particular study is not currently open for recruitment. The trial was initially listed on May 1st, 2024 and last updated on April 11th, 2024. While this specific trial is no longer enrolling participants, there are presently 116 alternative trials actively seeking candidates."

Answered by AI

Can individuals younger than 20 years old participate in this study?

"To be eligible for this study, participants must fall within the age range of 20 to 75 years. It is noteworthy that there are separate trials available for individuals under 18 and those over 65 years old; specifically, there are six trials catering to pediatric patients and a significant number of 110 trials aimed at the elderly population."

Answered by AI

Recent research and studies

Journal of Bone and Joint SurgeryJournal

The Societal and Economic Value of Rotator Cuff Repair

Mather, Richard C., Lane Koenig, Daniel Acevedo, Timothy M. Dall, Paul Gallo, Anthony Romeo, John Tongue, and Gerald Williams. 2013. “The Societal and Economic Value of Rotator Cuff Repair”. Journal of Bone and Joint Surgery. Ovid Technologies (Wolters Kluwer Health). doi:10.2106/jbjs.l.01495.

International OrthopaedicsJournal

Biologic Augmentation of Rotator Cuff Repair with Mesenchymal Stem Cells During Arthroscopy Improves Healing and Prevents Further Tears: A Case-controlled Study

Hernigou, Philippe, Charles Henri Flouzat Lachaniette, Jerome Delambre, Sebastien Zilber, Pascal Duffiet, Nathalie Chevallier, and Helene Rouard. 2014. “Biologic Augmentation of Rotator Cuff Repair with Mesenchymal Stem Cells During Arthroscopy Improves Healing and Prevents Further Tears: A Case-controlled Study”. International Orthopaedics. Springer Science and Business Media LLC. doi:10.1007/s00264-014-2391-1.

clinicaltrials.govStudy

Varying Bone Marrow-Derived Mesenchymal Stem Cells Concentrations' Impact on Rotator Cuff Repair Outcomes

2024. "Varying Bone Marrow-Derived Mesenchymal Stem Cells Concentrations' Impact on Rotator Cuff Repair Outcomes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06361797.

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