FDG PET/MR Imaging for Chronic Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if a special scan, called a PET/MRI, can help doctors identify the root cause of chronic pain, particularly after joint surgeries. By pinpointing the pain source, doctors might treat it more effectively. Participants will have undergone either joint replacement surgery or a less invasive procedure, such as arthroscopy. Ideal candidates include those who experience persistent pain after joint surgery or those who are now pain-free post-surgery. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could enhance pain management for future patients.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team to get a clear answer.
What prior data suggests that this PET/MRI scan using FDG is safe for identifying the source of chronic pain?
Research has shown that both total joint replacement and less invasive procedures like arthroscopy are generally safe for patients. One study found that total joint replacement surgeries often succeed, with most patients experiencing fewer complications and shorter hospital stays. Another study demonstrated that short-stay programs for hip and knee replacements are safe and effective, matching the results of standard care.
For less invasive procedures like arthroscopy, the safety outlook remains positive. Although some patients might require more extensive surgery later, the initial procedure is usually well-tolerated. These minimally invasive surgeries often result in shorter hospital stays and are considered safe options for joint problems.
Overall, both treatments are widely used and generally safe, with studies supporting their effectiveness and safety in most cases.12345Why are researchers excited about this trial?
Researchers are excited about the trial involving FDG PET/MR imaging for peripheral pain generators because it explores a novel approach to understanding pain sources in joint procedures. Unlike traditional imaging methods, this technique combines PET and MR imaging to provide detailed insights into both metabolic activity and structural changes in the joints. This dual approach could potentially identify pain sources more accurately and help tailor more effective treatment plans for patients who have undergone joint surgeries like arthroplasty and arthroscopy. By improving our understanding of pain mechanisms post-surgery, this trial could lead to better management strategies and outcomes for patients.
What evidence suggests that a PET/MRI scan using FDG is effective for identifying the source of chronic pain?
This trial will compare different surgical procedures for joint issues. Studies have shown that replacing a joint, such as a hip or knee, effectively reduces pain. About 90% of patients who experienced moderate pain before surgery reported little to no pain five years later. Participants in this trial may undergo total joint replacement (arthroplasty) or a less invasive procedure like arthroscopy. Arthroscopy can improve muscle strength and speed up recovery, though some patients might still require additional surgery in the future. Both treatments aim to enhance movement and quality of life, with strong evidence supporting their effectiveness in managing long-term joint pain.16789
Who Is on the Research Team?
Sandip Biswal, MD
Principal Investigator
University of Wisconsin, Madison
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants undergo a PET/MRI scan using FDG to identify sources of chronic pain
Follow-up
Participants are monitored for changes in pain scores and imaging findings over time
What Are the Treatments Tested in This Trial?
Interventions
- FDG radiotracer
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
PPSP subjects who have undergone hip (or knee) joint arthroplasty (i.e., open surgical procedure for joint replacement). * 6 month post-op scans * 12 month post-op scans * 18 month post-op scans
PPSP subjects who have undergone hip (or knee) arthroscopy (i.e., less invasive joint surgical procedure involving scopes and lower profile surgical tools) \- 6 month post-op scans
Asymptomatic subjects who have undergone hip or knee arthroscopy. \- single scan during one study visit (up to 3.5 hours)
Asymptomatic subjects who have undergone total hip or total knee arthroplasty. \- single scan during one study visit (up to 3.5 hours)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Wisconsin, Madison
Lead Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
Arthroscopy Association of North America (AANA)
Collaborator
Citations
Better outcomes after minimally invasive surgeries ...
MIS TKA procedures have been introduced to minimize quadriceps disruption, resulting in better quadriceps strength [19, 41, 44]. Furthermore, ...
Does Previous Hip Arthroscopy Affect the Clinical ...
Failure of hip arthroscopy procedures and the need for subsequent total hip arthroplasty (THA) have been estimated to be as high as 16%.
3.
bmcmusculoskeletdisord.biomedcentral.com
bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-024-07813-3Arthroscopic surgery is not superior to conservative treatment ...
The results of data synthesis demonstrated that patients with OA did not benefit more from arthroscopy than from conventional managements in ...
Hip arthroscopy: Indications, outcomes and complications
We aim to review hip arthroscopy in the light of recent literature and will discuss the current indications, outcomes and complications of the procedure.
Overview of surgical therapy of knee and hip osteoarthritis
INTRODUCTION. The goals of the surgical management of patients with osteoarthritis (OA) are to reduce or eliminate pain, minimize disability ...
Evaluation of Comparative Efficacy and Safety of Surgical ...
This systematic review and meta-analysis evaluates the efficacy and safety associated with different surgical approaches for total hip ...
Minimally Invasive Versus Conventional Joint Arthroplasty
The purpose of this article is to review minimally invasive surgical options for the treatment of osteoarthritis of the hip, knee, and shoulder. We also examine ...
Minimally Invasive Surgery of the Hip Versus Standard ...
The purpose of this study is to determine if there is a difference in terms of length of hospital stay and post-operative outcomes between patients whose total ...
9.
stanfordhealthcare.org
stanfordhealthcare.org/medical-treatments/m/minimally-invasive-joint-replacement-surgery.htmlMinimally Invasive Joint Replacement Surgery
Surgeons can now safely replace hip and knee joints through skin incisions as small as 3-4 inches. But minimally invasive surgery is not defined by the length ...
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