CLINICAL TRIAL

Low Fat Diet (LFD) for Dietary Fats

Recruiting · 18+ · All Sexes · New Brunswick, NJ

Lean and Obese: Dietary Inflammation

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About the trial for Dietary Fats

Eligible Conditions
Dietary Fats · Obesity · Inflammation

Treatment Groups

This trial involves 2 different treatments. Low Fat Diet (LFD) is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Low Fat Diet (LFD)
OTHER
+
High Fat Diet (HFD)
OTHER
Experimental Group 2
Low Fat Diet (LFD)
OTHER
+
High Fat Diet (HFD)
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Men or Women
Age 50-75 years (only postmenopausal women > 2 years)
You are 20-25 kg/m2 or 30-40 kg/m2. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Change from LFD (5 days) to HFD (5 days) over an average of 6 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Change from LFD (5 days) to HFD (5 days) over an average of 6 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Low Fat Diet (LFD) will improve 3 primary outcomes, 8 secondary outcomes, and 4 other outcomes in patients with Dietary Fats. Measurement will happen over the course of Change over 5 hour MMTT.

Change in Osteocalcin in response to a meal
CHANGE OVER 5 HOUR MMTT
Serum bone formation and energy metabolism marker
Change in CTX in response to a meal
CHANGE OVER 5 HOUR MMTT
Serum bone resorption marker
Change in Triglycerides in response to a meal
CHANGE OVER 5 HOUR MMTT
Serum lipid response to a meal
Change in PINP in response to a meal
CHANGE OVER 5 HOUR MMT
Serum bone formation marker
Change in Endotoxin in response to a meal
CHANGE OVER 5 HOUR MMT
Serum inflammatory response to a mixed meal tolerance test (MMT)
Change in Glucose in response to a meal
CHANGE OVER 5 HOUR MMT
Serum glycemic response to a meal
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Who is running the study

Principal Investigator
S. A. S. P. R.
Prof. Sue A. Shapses Ph.D., RD, Professor
Rutgers, The State University of New Jersey

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get obesity a year in the United States?

  1. There is a strong increase in the relative proportion of U.S.-born Whites at risk for obesity. This is unlikely to be due to the increase in obesity rates per se. 2. Obesity has a strong age effect; at all ages, an increasing proportion of people are accumulating excess adipose tissue. 3. Overweight children have higher rates of obesity in adulthood. 4. Increasing socioeconomic indicators were associated with higher rates of obesity; individuals with low socioeconomic status are most likely to fall outside the normal range for body mass index.
Anonymous Patient Answer

What are common treatments for obesity?

The treatment options for obesity are numerous and highly variable. Weight loss surgery has been an option in the past. More recently other weight loss methods, such as low-fat diets and exercise have been introduced. The first line of therapy for obesity includes lifestyle changes and, if unsuccessful, other therapeutic modalities such as medication and injections.\n

Anonymous Patient Answer

What causes obesity?

The main environmental causes of obesity are an unhealthy diet and lack of exercise. A healthier diet and increased physical activity could lower the risk of obesity. The high prevalence of obesity in children may be due to parents' reluctance to promote a healthy weight or because health professionals are not skilled at tackling childhood obesity. Prevention programmes must aim for people to have healthier lifestyles and have better control of their weight and diet. These can help to lower the risk of obesity.

Anonymous Patient Answer

What are the signs of obesity?

Obesity-related symptoms, such as excess body fat and high blood pressure, worsen during the winter, possibly as a result of lower daytime activity and less physical activity during colder weather. People can avoid obesity by exercising regularly, eating more vegetables and avoiding sugar-containing drinks and high fat snacks during the winter.

Anonymous Patient Answer

Can obesity be cured?

This is one of several studies using a very similar treatment protocol to the one used in this study. Both treatment groups showed significant gains in body weight, BMI and waist circumference within 6 months, following the 8-week treatment. The majority of participants in both groups continued their improvements for the following six months. Overall, our findings suggest that, in the short term, obesity in an otherwise healthy weight group can be successfully treated.

Anonymous Patient Answer

What is obesity?

Obesity is a condition where body fat is abnormally distributed, leading to the formation of abdominal obesity or ectopic fat deposition in other areas. It is particularly common in the Middle-Eastern region of the world with the highest numbers of cases being found in the Americas and Europe.\n

Anonymous Patient Answer

How does low fat diet (lfd) work?

Based on a controlled fld intervention, we observed a significant improvement of metabolic parameters that were associated mainly to changes in adiposity and not to improvements in muscular strength as is often reported.

Anonymous Patient Answer

What is the primary cause of obesity?

There is no primary underlying cause for obesity. Obesity is not caused by heredity but rather is influenced by genes, environment, behavior and lifestyle factors. The primary cause of obesity is the increased intake of calories; however, obesity can be caused by changes in the amounts of calories, calories and the quality of calories eaten.

Anonymous Patient Answer

Have there been any new discoveries for treating obesity?

Although there is many evidence in the literature for many types of drugs, they are little used today in clinical practice. Although we could have used many drugs over the past 20 years, they were not effective. There are a good number of new exciting new pharmacological targets on the horizon though. Most of these drugs will be of the new, rational design type. Although there are some exceptions, this may solve the obesity problem

Anonymous Patient Answer

What does low fat diet (lfd) usually treat?

Patients are a huge part of clinical outcomes and must actively participate in care to maximize treatment outcomes. When comparing diet-alone in weight loss and weight maintenance with combination diet-intervention, there is no significant difference. But the weight-related QOL questionnaire can be an additional tool to assess if an individual is benefiting from a specific weight loss intervention or a combination of diet-intervention and behavior treatment. The overall results of the study should be analyzed together with other studies in order to determine if an intervention is effective and/or whether an individual is responding effectively to the intervention.

Anonymous Patient Answer

Is low fat diet (lfd) typically used in combination with any other treatments?

There is a need for more rigorous controlled clinical trials with a long follow-up and standardized clinical approaches for evaluating the use of lfd in combination with other therapeutics.

Anonymous Patient Answer

Is low fat diet (lfd) safe for people?

Findings of our controlled trial on LFD did not support claims of an increased risk for cardiovascular disease in people with a healthy lifestyle. It is a public health concern to encourage people to lose weight and avoid unhealthy dietary patterns as they continue to be associated with an increased risk for CVD.

Anonymous Patient Answer
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