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Procedure

Arterial Catheter Use in Critical Care Management (GRACE Trial)

N/A

Waitlist Available

Led By David Feller-Kopman, MD

Research Sponsored by Dartmouth-Hitchcock Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up inpatient hospitalization (approximately 1 to 30 days) and experiencing 0 to 1 bloodstream infections

Awards & highlights

GRACE Trial Summary

This trialwill compare using fewer invasive arterial lines to regular use to see if it's as effective.

Who is the study for?

This trial is for patients in the medical intensive care unit who can be monitored without an arterial catheter. Excluded are those with severe pulmonary hypertension, unreliable pulse oximetry or blood pressure monitoring, a need for frequent arterial blood gas tests after repeated failures, or on extracorporeal membrane oxygenation.Check my eligibility

What is being tested?

The study compares two approaches to using invasive arterial lines: 'restricted-use' where they're used less often and 'standard-use' where they're part of regular care. The goal is to see if restricted use is just as good (non-inferior) as standard use.See study design

What are the potential side effects?

Potential side effects from using arterial catheters include blood clots, infections in the bloodstream, complications related to low blood pressure and vasopressors, kidney failure due to poor circulation (ischemia), and issues from mechanical ventilation.

GRACE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ inpatient hospitalization (approximately 1 to 30 days) and receiving approximately 0 - 10 blood transfusions

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~inpatient hospitalization (approximately 1 to 30 days) and receiving approximately 0 - 10 blood transfusions

This trial's timeline: 3 weeks for screening, Varies for treatment, and inpatient hospitalization (approximately 1 to 30 days) and receiving approximately 0 - 10 blood transfusions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of days hospitalized in the medical intensive care unit (length-of-stay)

Secondary outcome measures

Number of ABG measurements

Number of blood transfusions received during hospitalization (packed red blood cell transfusions)

Number of days hospitalized in a non- medical intensive care unit (Hospital length-of-stay)

+9 more

GRACE Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Restricted-use of arterial cathetersExperimental Treatment1 Intervention

Group II: Standard-use of arterial cathetersActive Control1 Intervention

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Dartmouth-Hitchcock Medical CenterLead Sponsor

524 Previous Clinical Trials

2,542,641 Total Patients Enrolled

David Feller-Kopman, MDPrincipal InvestigatorDartmouth-Hitchcock Medical Center

1 Previous Clinical Trials

125 Total Patients Enrolled

Media Library

Restricted-use of arterial catheter (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05411315 — N/A

Kidney Failure Research Study Groups: Restricted-use of arterial catheters, Standard-use of arterial catheters

Kidney Failure Clinical Trial 2023: Restricted-use of arterial catheter Highlights & Side Effects. Trial Name: NCT05411315 — N/A

Restricted-use of arterial catheter (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05411315 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an ongoing recruitment of participants for this clinical trial?

"This clinical trial is still recruiting as indicated by the information on clinicaltrials.gov, which was last updated on February 13th 2023. This research study initially went online for recruitment purposes in October 17th 2022."

Answered by AI

What is the enrollment rate in this medical experiment?

"Affirmative. Clinicaltrials.gov has the latest information on this active investigation which was first announced on October 17th 2022 and was most recently modified on February 13th 2023. The research team is looking to recruit 456 people from a single centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment

David J. Feller-Kopman 2022. "Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05411315.