Combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream for Squamous Cell Carcinoma

Carilion Clinic Dermatology and Mohs Surgery, Roanoke, VA
Squamous Cell CarcinomaCombination topical 5-fluorouracil 5% / calcipotriene 0.005% cream - Drug
Eligibility
18 - 100
All Sexes
What conditions do you have?
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Study Summary

This trialwill test if combining two creams can treat skin cancer with fewer side effects and a shorter treatment duration.

Eligible Conditions
  • Squamous Cell Carcinoma

Video Summary

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

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1
Capsaicin Palmitate
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Topical Calcipotriene Ointment
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5-fluorouracil

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: 6-8 wks

3-4 wks
Cosmetic appearance
6-8 wks
Cancer resolution on histopathology
Final scar length

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Capsaicin Palmitate
1
Topical Calcipotriene Ointment
1
5-fluorouracil

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

3 Treatment Groups

14 day medication group
1 of 3
7 day medication group
1 of 3
Placebo group
1 of 3

Experimental Treatment

Non-Treatment Group

30 Total Participants · 3 Treatment Groups

Primary Treatment: Combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream · Has Placebo Group · Phase < 1

14 day medication group
Drug
Experimental Group · 1 Intervention: Combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream · Intervention Types: Drug
7 day medication group
Drug
Experimental Group · 1 Intervention: Combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream · Intervention Types: Drug
Placebo group
Drug
PlaceboComparator Group · 1 Intervention: Nourivan Base Cream · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6-8 wks

Who is running the clinical trial?

Carilion ClinicLead Sponsor
67 Previous Clinical Trials
12,290 Total Patients Enrolled
Mariana Phillips, MDPrincipal InvestigatorCarilion Clinic Dermatology
1 Previous Clinical Trials
1,600 Total Patients Enrolled
Joshua D Eikenberg, MDPrincipal InvestigatorCarilion Clinic Dermatology

Eligibility Criteria

Age 18 - 100 · All Participants · 0 Total Inclusion Criteria

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References

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