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Pre-Transplant Immunotherapy for Skin Cancer Prevention in Organ Transplant Recipients
Study Summary
This trial is investigating whether a combination of two drugs can help prevent skin cancer in people who have received organ transplants.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am a woman who cannot become pregnant or I have tested negative for pregnancy recently.I am 18 years old or older.I have skin growths that are thick, rough, or didn't improve with freezing treatments.My treatment area is close to a healing wound or a possible skin cancer.I am willing and able to participate in the study.I am waiting for an organ transplant and have had skin cancer that was not melanoma.I have had high calcium levels or vitamin D toxicity in the past.I have 4 to 15 visible skin lesions on my head, face, or upper arms.I have a DPD deficiency, increasing my risk for certain medication toxicities.
- Group 1: Topical Calcipotriol ointment plus 5-Fluorouracil cream
- Group 2: Topical vaseline plus 5-Fluorouracil 2.5% cream
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Topical 5FU received endorsement from the Food and Drug Administration?
"Our team at Power assessed the safety of Topical 5FU to be a 2 on their 1-3 scale, as this is currently in Phase 2. While evidence indicates that it's safe, no data exists yet for its efficacy."
What is the aggregate figure of participants in this research project?
"This trial is now closed and no longer recruiting patients. It was initially made available on January 1st 2023, but the last update to its listing was April 5th 2022. If you are searching for other studies involving immunotherapy, there are currently 853 trials that may be of interest; 326 clinical trials utilizing Topical 5FU in particular are presently looking for participants."
What prior experiments have featured Topical 5FU as part of their protocol?
"At the moment, 326 trials involving Topical 5FU are in progress with 103 at Phase 3. Woolloongabba, Queensland features several of these clinical studies while a total 17193 locations have active assessments for this medication's efficacy."
What medical conditions can be addressed by utilizing Topical 5FU?
"Ophthalmologists and general practitioners often prescribe 5FU topically for disinfecting the eyes or treating conditions such as dry eye syndromes, malignant neoplasm of pancreas and pruritus ani."
Is there still room for individuals to participate in this experiment?
"Unfortunately, this trial is no longer looking to enroll participants as the last edit was made on April 5th 2022. However, if you are in search of other studies involving immunotherapy, there are 853 trials enlisting patients and 326 for Topical 5FU respectively."
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