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Aerobic Exercise for Multiple Sclerosis
Phase 1 & 2
Recruiting
Led By Lindsey B Wooliscroft, MD
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Aged 18-64 years
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
Study Summary
This trial is to see if exercising can help people with MS by promoting remyelination.
Who is the study for?
This trial is for adults aged 18-64 with a confirmed diagnosis of multiple sclerosis (MS) who have internet access and can do virtual visits. They must not be very active, pregnant, or have had recent MS treatments or relapses. Changes in their MS medication within the last 6 months or certain medications affecting tests are also disqualifiers.Check my eligibility
What is being tested?
The study is testing if aerobic exercise like stationary cycling can help repair nerve insulation damage caused by MS. Participants will either join an education group as a control or engage in the exercise program to see if it makes a difference.See study design
What are the potential side effects?
While specific side effects aren't listed for this trial, general risks may include muscle soreness, fatigue, and potential exacerbation of some MS symptoms due to physical activity.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 64 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ from baseline to week 24
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from baseline to week 24
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Secondary outcome measures
7-site skinfold test
Average heart rate (HR) zone during exercise sessions
Brain Myelin Water Fraction (MWF)
+3 moreOther outcome measures
6-Minute Timed Walk (6MTW)
9 Hole Peg Test
Activity Readiness Questionnaire (PAR-Q)
+12 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: MS: CycleExperimental Treatment1 Intervention
Twenty-two participants in the clinical trial arm will be randomized to MS:Cycle: an aerobic exercise intervention on a stationary ergometer. Participants will exercise thrice weekly for 30 minutes with graded supervision for 24 weeks.
Group II: MS: Take ControlActive Control1 Intervention
Twenty-two participants in the clinical trial arm will be randomized to MS: Take Control (MSTC): a monthly, hour-long MS education control group led by a trained facilitator.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic exercise
2000
Completed Phase 2
~1130
Find a Location
Who is running the clinical trial?
Oregon Health and Science UniversityLead Sponsor
973 Previous Clinical Trials
7,385,752 Total Patients Enrolled
29 Trials studying Multiple Sclerosis
2,156 Patients Enrolled for Multiple Sclerosis
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,964 Previous Clinical Trials
2,672,522 Total Patients Enrolled
18 Trials studying Multiple Sclerosis
1,748 Patients Enrolled for Multiple Sclerosis
Myelin Repair FoundationUNKNOWN
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- A doctor has confirmed that you have MS using specific guidelines from 2017.I am between 18 and 64 years old.Your somatosensory evoked potential test results show certain patterns that are not within the normal range.I have had a multiple sclerosis flare-up in the last 3 months.I haven't changed my MS treatment in the last 6 months.You regularly do more than 30 minutes of aerobic exercise each week.I have taken steroids for MS in the past month.I am taking 4-aminopyridine or dalfampridine and cannot stop it for SSEP tests.I cannot use a bike or treadmill for health reasons.I have a severe narrowing of my spinal canal.
Research Study Groups:
This trial has the following groups:- Group 1: MS: Cycle
- Group 2: MS: Take Control
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this medical research presently accepting participants?
"Clinicaltrials.gov indicates that this clinical trial is currently enrolling subjects, with the initial advertisement posted on April 29th 2021 and last updated on August 8th 2022."
Answered by AI
To what demographic is this experiment open?
"This clinical trial is open to those aged 18-64 who have been diagnosed with a neurological condition. To be considered for the study, individuals must fulfill the 2017 McDonald criteria for MS diagnosis, possess access to virtual visits and an internet enabled device, as well as demonstrate somatosensory evoked potential (SSEP) latency z-score ≥2 or inter-side difference in z-score ≥2 for P40."
Answered by AI
Is enrollment being offered to those aged under 75 years old for this clinical experiment?
"The conditions for this clinical trial requires participants to be between 18 and 64 years old. Separately, there are 95 trials running specifically for minors and 576 studies targeting individuals over 65 years of age."
Answered by AI
How many volunteers have enrolled in this experiment?
"Yes, recent information from clinicaltrials.gov affirms that this medical investigation is in the process of recruiting applicants. The trial was first unveiled on April 29th 2021 and most recently updated on August 8th 2022; it requires 60 participants to be enrolled at 1 site."
Answered by AI
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