Dr. Shadmehr Demehri, MD

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Massachusetts General Hospital

Studies Actinic Keratosis
Studies Plantar Keratosis
4 reported clinical trials
6 drugs studied

Affiliated Hospitals

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Massachusetts General Hospital
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Dana Farber Cancer Institute

Clinical Trials Shadmehr Demehri, MD is currently running

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Calcipotriene + 5-Fluorouracil

for Actinic Keratosis

This phase IIA study evaluates the effects of calcipotriene plus 5- fluorouracil immunotherapy for skin cancer prevention in organ transplant recipients. Solid organ transplant recipients are at high risk of developing skin cancer. Actinic keratosis (AK), is a premalignant skin lesion that can progress to squamous cell skin cancer. In this study, solid organ transplant recipients with multiple AKs are treated with topical calcipotriene and 5-FU to evaluate how effective this therapy is against AKs and if this could lower their risk of skin cancer. Topical calcipotriene is a form of vitamin D and is used to treat psoriasis. Prior research reported immunomodulatory effects in the skin induced by topical calcipotriene. Topical 5- fluorouracil is a chemotherapy agent and is one of the therapy options for multiple AKs in specific clinical scenarios. Prior research indicates that topical calcipotriene used together with topical 5-FU was more effective in treating multiple AKs than 5-FU alone in individuals with healthy immune system. This study is investigating now if similar beneficial effects can be seen in immunosuppressed individuals who are solid organ transplant recipients.
Recruiting1 award Phase 211 criteria

More about Shadmehr Demehri, MD

Clinical Trial Related6 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 1 Active Clinical Trial
Treatments Shadmehr Demehri, MD has experience with
  • Calcipotriol And 5-fluorouracil Cream
  • Calcipotriol And 5-FU Cream
  • Topical Calcipotriene Ointment
  • Topical Vaseline
  • Calcipotriene
  • Fluorouracil
Breakdown of trials Shadmehr Demehri, MD has run
Actinic Keratosis
Plantar Keratosis
Skin Cancer
Immunotherapy
Squamous Cell Carcinoma

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